摘要
目的ｐ１６、ｐＲｂ为肿瘤抑制基因，细胞周期调控因子。探讨Ｐ１６、ｐＲｂ在非小细胞肺癌中的作用。方法：采用免疫组织化学方法对３８例原发性非小细胞肺癌中ｐ１６、ｐＲｂ两因子表达情况进行研究。结果：ｐ１６、ｐＲｂ的阳性表达率分别为４７．４％和７６．３％。在５０％ｐＲｂ阳性的病例中，ｐ１６蛋白不表达或表达水平很低；在２１％ｐＲｂ阴性的病例中，ｐ１６蛋白具有较高的表达水平。结论：ｐＲｂ与ｐ１６蛋白在非小细胞肺癌中的表达呈负相关。
Objective:Both p16 and pRb are tumor suppressor genes and regulatory factors of cell cycle. The aim of the research is sutdy the expressions of p16、 pRb in primary nonsmall cell lung cancer (NSCLC)Methods:We detected p16 and pRb from 38 patients with NSCLC by means of immunohistochemistry. [WT5”HZ〗Results:p16 and pRb were detectable in 47.4% and 76.3% patients respectively. 50% of pRb positive cases had no or low p16 expression, while 21% of pRb negative ones showed high level of p16.Conclusions:The expression of pRb is inversely correlated with that of p16 in NSCLC.The expression of p16 might be negatively regulated by pRb.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1998年第4期340-342,共3页
Journal of China Medical University
基金
辽宁省自然科学基金
