摘要
目的:探讨黄体中期应用长效促性腺激素释放激素激动剂(GnRH-a)控制性超促排卵的启动时机对体外受精-胚胎移植技术(IVF-ET)结局的影响。方法:分析2008年1～12月黄体中期应用长效GnRH-a1.25mg单次肌内注射实施控制性超促排卵的IVF-ET129例,根据降调节14d前后的不同启动时间段分两组,比较不同启动时机的促排卵效果及其对体外受精结局的影响。结果:两组卵裂率、优质胚胎率、临床妊娠率、种植率对比,差异均无统计学意义(P>0.05),而降调节≥14d启动组启动日的促黄体生成激素(LH)、雌二醇(E2)值较低,用药时间较短,用药剂量较少,差异有统计学意义(P<0.05)。结论:在控制性超促排卵过程中,个体化用药有助于提高IVF-ET的结局。GnRH-a降调节后延迟启动时机有利于降低用药剂量及用药时间,继而可以减轻患者的经济负担和精神压力。
Objective： To explore the influence of different starting time of controlled ovarian hyperstimulation using long- acting gonadotropin- releasing hormone agonist （GnRH -a） during mid -luteal phase on the outcomes of in vitro fertilization- embryo transfer （IVF- ET）. Methods： 129 infertile patients with IVF - ET were registered in this study according to the implementation of controlled ovarian hyperstimulation using long- acting GnRH -a （a single intramuscular injection with 1.25mg） during mid -luteal phase from January to December 2008. All cases were divided into 2 groups according to the different starting time before or after down - regulation for 14 days, and the influences of different starting time on ovulation induction and IVF - ET outcomes were compared. Results ： There were no significant differences of cleavage rate, high -quality embryo rate, clinical pregnancy rate, and embryo implantation rate between the 2 groups （P 〉 0. 05）. The values of leuteinizing hormone （LH） and estradiol （E2 ） were lower in the group with starting time later than 14 days, and the administration time was shorter with less dosage. The differences were statistically significant （ P 〈 0.05 ）. Conclusion ： Personalized medicine can improve IVF - ET outcomes during the controlled ovarian hyperstimulation process. The delayed starting time after GnRH - a down - regulation is beneficial to the reduction of administration time and dosage, and then the relief of patients＇ financial burden and mental stress.
出处
《中国计划生育学杂志》
北大核心
2009年第8期485-487,共3页
Chinese Journal of Family Planning
