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应用不同剂量长效GnRHa(达菲林)降调节的临床效果分析 被引量：27

Analysis of long-term downregu lating effect of GnRHa at different closes
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摘要 目的:探讨IVF中GnRHa(达菲林)降调节的合适剂量。方法:回顾性分析采用黄体期长方案进行控制性超排卵临床妊娠病例147例,根据所用达菲林的剂量分为4组,分别为A组0.93-1.12mg(31例)、B组1.31mg(30例)、C组1.50mg(50例)和D组1.69-1.87mg(36例),比较各组间的治疗指标。结果:各组间垂体降调节时间、促性腺激素(Gn)使用时间、降调节后给予Gn前血清LH、取卵日血清P、ET日血清PRL水平均无显著性差异(P>0.05)。各组患者年龄、使用Gn总量、hCG注射日血清E2、取卵日血清E2、募集卵泡数、获卵数、MII卵数均有显著性差异(P<0.05)。结论:应根据患者的卵巢基础状态给予不同剂量的GnRHa行垂体降调节;高龄妇女及卵巢储备功能较差的患者,进行辅助生殖治疗中,长效GnRHa0.93mg(1/4支)已可达到控制性超排卵的垂体调节和抑制LH峰早现的作用。
作者 张学红 李丽斐 赵丽辉 石馨 贾学玲
机构地区 兰州大学第一医院辅助生殖医学中心
出处 《生殖与避孕》 CAS CSCD 北大核心 2005年第7期435-437,445,共4页 Reproduction and Contraception
关键词 体外受精 胚胎移植 达菲林 促性腺激素释放激素激动剂 控制性超排卵
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献10

  • 1赵晓明,陈珠萍,林其德.标准剂量和半量缓释型达必佳在体外受精-胚胎移植中治疗效果的比较[J].生殖与避孕,2002,22(4):243-246. 被引量：20
  • 2李晓红,武学清,王嵩,张晓,程慧虹,王素梅,陈菲.减量促性腺激素释放激素激动剂在促超排卵中的应用[J].生殖医学杂志,2003,12(3):146-149. 被引量：10
  • 3田莉.GnRH—a对体外受精患者卵巢甾体激素分泌作用的影响[J].国外医学：计划生育分册,2001,20(1):61-2.
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  • 5赵晓徽,随笑琳.两种剂量达必佳在IVF控制超排卵周期降调节中的应用[J].天津医科大学学报,2003,9(1):36-38. 被引量：4
  • 6Dal PL, Borini A, Trevisi MR, et al. Effect of reduced dose of trptorelin at the start of ovarian stimulation on the outcome of IVF: a ranmominized study. Hum Reprod, 2001, 16(7):1409-14.
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二级参考文献21

  • 1庄广伦,顾正田.Buserelin在体外受精超排卵中的作用及其对排卵前卵泡液的影响[J].中华妇产科杂志,1993,28(1):10-13. 被引量：21
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  • 5Prato BD, Borini A, Trevisi MR. Effect of reduced dose of triptorelin at the start of ovarian stimulation on the outcome of IVF: a randomized study [J]. Hum Reprod, 2001,16(7):1409-1414.
  • 6Hsieh Y, Tsai H, Chang C, et al. Comparison of a single half-dose, long-acting form of gonadotropin-releasing hormone analogue (GnRH-a) and a short-acting form of GnRH-a for pituitary suppression in a controlled ovarian hyperstimulation program [J ]. Fertil Steril,2000.73(4):817-820.
  • 7Dirnfeld M, Fruchter O, Yshai D. Cessation of gonadotropin-releasing hormone analogue (GnRH-a) upon down-regulation'versus conventional long GnRH-a protocol in poor responders undergoing in vitro fertilization[J]. Fertil Steril, 1999,72(3):406-411.
  • 8Kavic S, Sauer MV, Lindheim SR. Menses predict successful ovarian down-regulation using GnRH-a prior to IVF-ET[J]. J Assist Reprod Genet, 2000,17 (5) : 296-298.
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  • 10Bstandig B, Cedrin-Durnerin I & Hugues JN. Effec tiveness of low dose of gonadotropin releasing hormone agonist on hormonal flare up. J Assisted Reprod Genetics, 2000,17 : 1 13 ～ 117.

共引文献27

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引证文献27

二级引证文献188

生殖与避孕
2005年 第7期

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