摘要
应用单克隆抗体铺皿法分离受６０Ｃｏγ射线分次照射的小鼠脾脏Ｌ３Ｔ４、Ｌｙｔ２和Ｂ细胞，测定榄香烯对以上３种亚群细胞和Ｌ３Ｔ４、Ｌｙｔ２对Ｂ细胞３ＨＴｄＲ掺入的影响；同时测定ＳＯＤ活力和ＬＰＯ含量。结果表明：榄香烯提高亚群细胞的辐射抗性，增强了Ｌ３Ｔ４对Ｂ细胞的辅助调节作用，提高脾脏ＳＯＤ活力和降低ＬＰＯ含量。
The spleen lymphocytes in mice after fraction irradiation were separated into L 3T 4, Lyt 2 and B cells by a panning method with monoclonal antibodies. The effects of elemene on function and regulation of lymphocyte subsets were studied by using 3H TdR incorporation, the SOD activity and LPO content were measured. The results indicated that elemene could increase the radiation resistance of lymphoicyte subsets, enhance the helping effects of L 3T 4 on B cell, increase spleen SOD activity and decrease LPO content. The formation of the mechanism of protection may be due to scavenging free radical and relieving the damage of target.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
1998年第3期161-164,共4页
Journal of Radiation Research and Radiation Processing
关键词
淋巴细胞亚群
γ全身照射
榄香烯
保护作用
Lymphocyte subsets
Free radical
Peroxidation
γ ray whole body irradiation
Elemene
