摘要
目的评价心跳骤停（CA），心肺复苏自主循环恢复（ROSC）后临床亚低温治疗的有效性和安全性。方法计算机检索PubMed数据库（1966-01至2008—08）、中国学术期刊网全文数据库（CNKI，1994—01至2008-08）、万方数据库（1994-01至2008—08），收集心肺复苏ROSC后亚低温治疗的临床研究文献，并对符合纳入标准的文献结果进行荟萃（Meta）分析，比较ROSC后亚低温治疗和常温治疗的结果。结果7篇文献纳入Meta分析，合并分析表明，与常温治疗组相比，院外CA ROSC后亚低温治疗可提高患者的出院生存率[OR=2．29（95％CI，1．75～2．98），P〈0．01]、改善出院时神经功能[OR=2．04（95％CI，1．55-2．67），P〈0．01]和远期神经功能[OR=2．17（95％CI，1．44—3．27），P〈0．01]，但两组总的不良反应发生率差异无统计学意义。结论心肺复苏ROSC后亚低温治疗安全有效，可改善患者出院时和远期神经功能，提高出院生存率。
Objective To evaluate the efficacy and safety of cardiopulmonary resuscitation （CPR） with mild hypothermia therapy for restoration of spontaneous circulation （ROSC）after cardiac arrest （CA）. Methods The data about the efficacy and/or safety of CPR with mild hypothermia therapy after ROSC were chosen from PubMed Data Base （from Jan 1966 to Aug 2008）, and domestic literature data were chosen from CNKI （from Jan 1994 to Aug 2008）and Wangfang Data Base （from Jan 1994 to Aug 2008）by computer retrieval. Meta-analysis was applied to evaluate the result. In all the literature data conformed to inclusive criteria, mild hypothermia therapy was compared with normothermia. Results Seven clinical research papers were enrolled in Mata- analyzsis. Compared with normothermia group, the OR of the survival rate to discharged patients in mild hypothermia therapy group was 2.29 （95% CI 1.75-2.98, P〈0.01） , the OR of discharge and long-term cerebral functions were 2.04 （95% CI 1.55-2.67, P〈0.01） and 2.17 （95% CI 1.44- 3.27, P〈0.01 ） , respectively. The adverse reactions related to the therapy were not significantly different between two groups. Conclusions CPR with the mild hypothermia therapy for ROSC is safe and effective. It can improve discharge and long-term cerebral functions, and increase the survival rate of discharged patients.
出处
《中华生物医学工程杂志》
CAS
2009年第2期135-140,共6页
Chinese Journal of Biomedical Engineering
关键词
心肺复苏术
心脏停博
血液循环
低温
生存率
Cardiopulmonary resuscitation
Heart arrest
Blood circulation
Hypothermia
Survival rate
