摘要
从沿海藻类昆布(Thallus laminariae)中提取昆布多糖,经降解后得昆布寡糖。采用高脂饲料加小剂量链脲佐菌素法诱导SD大鼠2型糖尿病动物模型,成模后大鼠分为正常对照组,阴性对照组,二甲双胍组,昆布寡糖高、中、低剂量组,灌胃给予寡糖溶液8周,定期观察体重并采集血液标本进行检测。结果表明,昆布寡糖对糖尿病大鼠有明显的降低血糖,升高胰岛素,增加体重,降低甘油三酯、总胆固醇、游离脂肪酸,升高高密度脂蛋白胆固醇的作用,但对低密度脂蛋白胆固醇的影响不明显。可见,昆布寡糖对2型糖尿病大鼠具有明显治疗作用。
Thallus laminariae oligosaccharide was extracted and cut from Thallus laminariae. High-fat chow and streptozotocin were used to induce type 2 diabetc animal model of rat, then rats were divided into six groups： Normal group, Negative control group, Dimethylbiguanide group, High-dose group, Middle-dose group and Low-dose group, Thallus laminariae oligosaccharide solution was orally administered for 8 weeks, and body weight and blood were collected and detected Results are as follows： Significant decreases in blood glucose, triglyceride, total cholesterol, free fatty acids and significant increases in body weight, insulin level, HDL-C were detected in oligosaccharide-treated rats compared with negative control group rats, but the effect on LDL-C was not significant. These results indicated that Thallus laminariae oligosaccharide has significant therapeutic effect on type 2 diabetic rats.
出处
《广东海洋大学学报》
CAS
2009年第4期46-50,共5页
Journal of Guangdong Ocean University
基金
广东省科技局项目(0609084)"海洋巨藻活性寡糖提取及天然降糖制剂的研究"
关键词
昆布寡糖
2型糖尿病
血糖
Thallus laminariae oligosaccharide
type 2 diabetes： blood glucose
