摘要
采用应激小鼠实验模型，观察疏肝健脾汤对应激腹泻小鼠中胃肠激素５羟色胺（５ＨＴ）的实验作用。结果中药大剂量组、中药小剂量组、西药得舒特组分别与应激腹泻组比较腹泻指数有显著差异（Ｐ＜０．００２，Ｐ＜０．０５，Ｐ＜０．０１）。中药大，小剂量组之间相比较有显著差异（Ｐ＜０．０５）。中药大、小剂量组在应用疏肝健脾汤后与应激腹泻组比较，血清５ＨＴ浓度有明显差异（Ｐ＜０．００１，Ｐ＜０．０５）。实验研究证实，疏肝健脾法对血清５ＨＴ有明显的调节作用。
Experimentalmodeloftheirritablemicewasusedto observetheexperimentalfunctionofLiverSoothingandSpleenStrengtheningDecoctiontogasrtointestinalhormone5Hydroxytryptamine(5HT)inthemicewithirritablediarrhea.TheresultsshowedthatthereweresignificantdifferencesindiarrheadataincomparisonofthelargedosegroupofChinesemedicine,thesmalldosegroupofChinesemedicine,theDicetelgrouprespectivelywiththegroupofirritablediarrhea(P<0002,P<005,P<001).Therewassignificantdifferenceincomparisonbetweenthelargedosegroupandthesmalldosegroup(P<0.05).Therewassignificantdifferenceinconcentrationinserum5HT incomparisonofthelargedosegroupandthesmalldosegroupafterapplicationofLiverSoothingandSpleenStrengtheningDecoctionwiththeirritablediarrheagroup(P<0001,P<005).Theexperimentalstudyprovedthatthemethodtosoothetheliverandstrengthenthespleenhasanobviousregulatingfunctiontoserum5HT.
出处
《上海中医药大学学报》
CAS
1999年第2期46-48,共3页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
上海市教委科技发展基金
关键词
疏肝健脾汤
小鼠
5-羟色胺
实验研究
LiverSoothingandSpleenStrengtheningDecoction,mouse,5Hydroxytryptamine,experimentalstudy
