摘要
目的建立川贝枇杷糖浆中薄荷脑含量测定方法。方法采用毛细管气相色谱法(GC)。色谱条件:DB-WAX毛细管柱(30m×0.319mm×0.50μm);载气:氮气;柱前压为500kPa;柱温110℃,分流比为25∶1;进样口温度为250℃;检测器温度为250℃。结果三种市售川贝枇杷糖浆样品中的薄荷脑含量分别为0.154mg/mL、0.203mg/mL、0.109mg/mL,其中郑州某药业股份有限公司产品符合2005版药典的规定,其余两个品种的含量均稍偏低。结论所建立的方法简便,可行,重现性好,可用于市售川贝枇杷糖浆中薄荷脑含量的测定。
Objective To test the content of menthol in Chuanbei Pipa Syrup（CPS）by GC, and to evaluate its quality. Methods The content of menthol in CPS was determined by capillary gas chromatography. DB- WAX capillary column （30 m × 0. 319 mm×0. 50μm） was used with nitrogen as carrier gas. The precolumn pressure was 500 kPa and the column temperature was at 110 ℃ with split ratio of 25 ： 1. The temperature was set at 250 ℃ for sample injection and for the detector. Results The content of menthol in CPS produced by Henan Pharmaceutical Co. , Ltd. , Zhengzhou Pharmaceutical Co. , Ltd. and Yunan Pharmaceutical Co. , Ltd. was 0. 154 mg/mL, 0. 203 mg/mL and 0. 109 mg/mL, respectively. Of them, the menthol content in CPS produced by Zhengzhou Pharmaceutical Co. , Ltd. met the requirements of Pharmacopoeia（2005 edition）, and that of the other two species was slightly lower. Conclusion The methods are convenient, reliable and accurate for the determination of menthol content in Chuanbei Pipa Syrup.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2009年第4期361-363,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
