摘要
目的考察金银花、连翘药对配伍对挥发油化学成分的影响。方法采用气-质联用系统对金银花、连翘药材以及药对配伍中的挥发油进行分析,评价配伍对挥发油成分及含量的影响。结果采用GC-MS对金银花、连翘药材和药对挥发油的成分进行分析比较,发现金银花挥发油中检出的香叶醇、十四烷酸甲基酯、十六烷酸乙基酯、荧蒽、9,12,15-十八碳三烯酸甲基酯、亚油酸等成分和连翘挥发油中检出的樟脑烯、α-松油烯、紫苏醇、蒎烯、棕榈醛、β-水茴香萜等成分在药对挥发油中未检出,而相对于单煎所得的挥发油,药对挥发油中新增成分有柠檬烯、异长松叶烯、十九烷等。结论金银花、连翘药对配伍对所提挥发油的成分和含量都有较大的影响。
Objective To discuss the influence of drug compatibility on the components of the volatile oil in Flos Lonicerae and Fructus Forsythiae. Methods GC - MS system was used to analyze the volatile oil in Flos Lonicerae, Fructus Forsythiae and their combination. The effect of compatibility on the components and content of volatile oil was evaluated. Results The results of GC -MS showed that geranilo, tetradecanoic acid methyl ester, hexadecanoic acid ethyl ester, fluoranthene, 9, 12, 15 - Oetadecatrienoic acid ethyl ester and linoleic acid was detectable in Flos Lonicerae but was undeteetable in the drug pair; camphene, alpha - terpinene, perilla alcohol, 2 - beta - pinene, beta - hexadecanal, phellandrene was detectable in Fructus Forsythiae but was undetectable in the drug pair; limonene, isolongifolene, nonadecane was detectable in the drug pair but was undetectable in the two single drugs. Conclusion The compatibility of the drug pair has an effect on components and contents in the volatile oil of Flos Lonicerae and Fructus Forsythiae.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2009年第4期358-360,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
药对
金银花
连翘
挥发油
气质联用
Drug pair
Flos Lonieerae
Fruetus Forsythiae
Volatile oil
GC - MS
