法舒地尔对急性脑梗死患者血浆N0和ET-1的影响被引量：6

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摘要目的观察法舒地尔对急性脑梗死患者血浆一氧化氮和内皮素-1的影响,探讨该药的作用及机制。方法将69例发病48h内的急性脑梗死患者随机分为治疗组35例,对照组34例,治疗组除基础治疗外加用法舒地尔60mg/d,治疗前及治疗15d后分别进行神经功能缺损评分,同时测定血浆一氧化氮(NO)及血管内皮素-1(ET-1)水平。结果治疗后治疗组及对照组血浆NO水平明显升高(P<0.05),神经功能缺损评分明显下降(P<0.05)。治疗组血浆NO水平较对照组明显升高(P<0.05),ET-1水平及神经功能缺损评分均较对照组明显下降(P<0.05)。结论法舒地尔能有效的改善血管内皮功能,保护神经细胞,降低神经功能缺损程度。

作者洪丽王献

机构地区河南省安阳地区医院

出处《中国实用医药》 2009年第5期148-149,共2页 China Practical Medicine

关键词法舒地尔急性脑梗死 NO 血管内皮素-1

分类号 R743.3 [医药卫生—神经病学与精神病学]

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