摘要
目的探讨环氧化酶-2(COX-2)在尖锐湿疣组织中的表达及与细胞增殖和血管增殖的关系。方法用免疫组织化学SP法检测55例尖锐湿疣患者皮损的COX-2、增殖细胞核抗原(PCNA)、血管内皮生长因子(VEGF)和CD34的表达。结果55例CA患者中31例(56.4%)为COX-2阳性,24例(43.6%)阴性,正常对照组20例均为阴性。CA患者均为PCNA阳性,正常对照组10例PCNA阳性。COX-2阳性组PI值明显高于COX-2阴性和正常对照组(P<0.05)。55例CA患者中,VEGF阳性46(83.6%)例,阴性9(16.4%)例;正常对照组中VEGF阳性6(30%)例,阴性14(70%)例。CA组织中COX-2与VEGF表达存在显著正相关(P<0.05)。COX-2阳性患者的MVD值为(30.77±5.64),明显高于COX-2阴性者(P<0.05)。结论COX-2在CA皮损表达显著增高,且可能通过影响血管增生而对其细胞增殖起重要作用。
[Objective] To investigate the expression of COX-2 in condyloma acuminatum （CA） and its relationship with the proliferation in tissues. [Methods] The expression of COX-2, VEGF, PCNA and CD34 were detected by the s-p immunohistochemistry method, and the relationship between them was analyzed. [Results] The expression of cox-2 and PCNA in patients with CA was 56.4% and 100%, respectively. The PI value of COX-2 positive tissue was significantly higher than those of COX-2 negative group and control group. 46 （83.6%） CA tissues were VEGF positive, and there was a significantly relationship between the expression of VEGF and cox-2 （P 〈0.05）. MVD in patients with cox-2 positive was higher than that in patients with cox-2 negative. [Conclusions] The over expression of COX-2 protein in CA induces cell and vascular proliferation, which gave a new way to treating CA.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2009年第12期1898-1900,共3页
China Journal of Modern Medicine
基金
湖南省科技厅资助课题(No:olssy2008-14)
湖南省人民医院仁术科研基金项目
