摘要
A（H1N1）流感病毒是2009年3-4月在美国和墨西哥发现的一种流感病毒变异的新病毒株。这类流感疫情的蔓延引起了世界各国和世界卫生组织的严重关注。本文介绍了A（H1N1）流感新病毒株及感染这种病毒患者的症状，A（H1N1）流感病毒的致命力和传播，流感病毒变异对抗病毒药的抗药性，以及1918年流感大流行病毒聚合酶特性，人流感病毒和禽流感病毒聚合酶的结晶结构及其在感染中的作用。据此，提出了抗流感病毒药的筛选思路和研究方向，为抗流感病毒新药的设计和开发提供有益的参考。
A（ H1N1 ） influenza virus is a novel strain of influenza virus mutant, which was found in March to April 2009 in USA and Mexico. The spread of epidemic influenza brings about a serious attention by every country in the world and World Health Organization. In this paper,the A（ H1N1 ） influenza virus and its symptom,virulence and spread are introduced. Meanwhile,the mutant＇ s resistance to anti-influenza drugs,the characterization of the 1918 pandemic influenza virus polymerase, the crystal structure of human and avian influenza virus polymerase and its action in influenza are also discussed. Accordingly, we put forward the screening ideas and research orientation for anti-influenza virus drugs, which will be a beneficial reference for the further design and development of new antiinfluenza virus drugs.
出处
《食品与药品》
CAS
2009年第4期1-3,共3页
Food and Drug
