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抗病毒新药奥司他韦的研究进展 被引量：5

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摘要 奥司他韦是一种神经氨酸酶强效抑制剂,主要用于流行性感冒的防治。本文主要介绍其药动学、药效学及耐药性等方面的研究进展。该药疗效好、安全性高,但对流感病毒的耐药问题需进一步观察和研究。
作者 蔡宝祥 应永秋
机构地区 浙江省台州市立医院药剂科
出处 《安徽医药》 CAS 2006年第7期533-535,共3页 Anhui Medical and Pharmaceutical Journal
关键词 奥司他韦 流行性感冒 研究进展
分类号 R978.7 [医药卫生—药品]
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参考文献18

  • 1Treanor JJ,Hayden FG,Vrooman PS,et al.Efficacy and safety of oralneuraminidase inhibitor oseltamivir in treating acute influenza[J].JAMA,2000,283(8):1061-1065.
  • 2He G,Massarella J,Ward P.Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802.[J].Clin Pharmacokinet,1999,37:471-474
  • 3李雪宁,诸骏仁,王浩,周臻,葛庆华.奥司他韦及其活性代谢物在健康人体的药动学[J].中国临床药学杂志,2002,11(5):259-262. 被引量：13
  • 4Massarella J,He G,Dorr A,et al.Theaphrmacokinetics and tolerability of the oral neuraminidase inhibitor oseltamivir (Ro 64-0796/GS4104)in healthy adult and elderly volunteers[J].J Clin Pharmacol,2000,40(8):836-839.
  • 5He G,Massarella J,Aitken M,et al.The pharmacokinetics and safety of the oral neuraminidase inhibitor Ro 64-0796/GS4104 when administered concurrently with cimetidine or probenecid in healthy subjects[J].J Antimicrob Chemother,1999,44:44.
  • 6Sidwell RW,Bailey KW,Bemis PA,et al.Influence of treatment schedule and viral challenge dose on the in vivo influenza virus inhibitory effects of the orally and ministered neuraminidase inhibitor GS 4104.[J].Antivir Chem Chemother,1999,10:187.
  • 7Mendel DB,Tai CY,Escarpe PA,et al.Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection.[J].Antimicro Agents Chemother,1998,42:640.
  • 8Hayden FG,AtmarRL,Schilling M,et al.Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza[J].N Engl.J,1999,341(18):1336-1339
  • 9Treanor JJ,Hayden FG,Vrooman PS,et al.Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza:a randomized controlled trial[J].JAMA,2000,283(3):1016-1020
  • 10Nicholson KG,Aoki FY,Osterhaus AD,et al.Efficacy and safety of oseltamivir in treatment of acute influenza:a randomised controlled trial[J].Lancet,2000,355:1845-1848.

二级参考文献17

  • 1Hayden FG,Hay AJ. Emergence and transmission of influenza A viruses resistant to amantadine and rimantadine. Curr Top Microbiol Immunol,1992,176:119-130.
  • 2Whitley RJ,Hayden FG,Reisinger KS,et al. Oral oseltamivir treatment of influenza in children. Pediatr Infect Dis J,2001,20:127-133.
  • 3Upshur RE,Knight K,Goel V. Time-series analysis of the relation between influenza virus and hospital admissions of the elderly in Ontario,Canada,for pneumonia,chronic lung disease,and congestive heart failure. Am J Epidemiol,1999,149:85-92.
  • 4Narukawa M,K Minezaki K,Okubo M,et al. Impact of an influenza pandemic on the mortality of congestive heart failure in older Japanese:the 1998 Japanese influenza pandemic. J Am Geriatr Soc,2001,49:689-690.
  • 5Martin C,Mahoney P,Ward P,et al. Oral oseltamivir reduces febrile illness and is safe in patients with chronic cardiac and/or respiratory disease. World Congress on Lung Health,Florence,2000.
  • 6Kaiser L,Wat C,Mills T,et al. Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations. Arch Intern Med,2003,163:1667-1672.
  • 7Treanor JJ,Hayden FG,Vrooman PS,et al. Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza:a randomized controlled trial. US Oral Neuraminidase Study Group. JAMA,2000,283:1016-1024.
  • 8Massarella JW, He GZ, Dorr A, et al. The pharmacokinetics and tolerability of the oral neuraminidase inhibitor oseltamivir (Ro 64-0796/GS4104) in healthy adult and elderly volunteers[J]. Clin Pharmacol,2000.40:836.
  • 9Treanor J J, Hayden FG, Vrooman PS, et al. Efficacy and safety of oral neuraminidase inhibitor oseltamivir in treating acute influenza [J]. JAMA, 2000,283(8):1061.
  • 10Wiltshire H, Wiltshire B, Citron A, et al. Development of a high-performance liquid chromatographic-mass spectrometric assay for the specific and sensitive quantification of RO 64-0802, an anti-influenza drug, and its pro-drug, oseltamivir, in human and animal plasma and urine[J]. J Chromatography B, 2000,745: 373.

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安徽医药
2006年 第7期

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