摘要
目的探讨女性生殖道沙眼衣原体感染患者宫颈分泌物及血清中IL-2、IL-6的水平及其意义。方法采用放射免疫法分别检测40例衣原体感染的女性患者(试验组1)和15例非衣原体感染正常女性(对照组)的宫颈分泌物IL-2、IL-6的水平;同时采用放射性免疫法分别检测15例衣原体感染女性(试验组2)和15例非衣原体感染正常女性(对照组)的血清IL-2、IL-6的水平。结果40例衣原体感染的女性患者宫颈分泌物中IL-2水平明显高于对照组(P<0.05),而两组宫颈分泌物的IL-6水平无明显差异(P>0.05)。15例衣原体感染的女性患者和15例非衣原体感染的女性血清中IL-2、IL-6水平无明显差异(均P>0.05)。结论生殖道局部细胞因子IL-2在沙眼衣原体感染的发病机制中可能起重要作用。IL-2、IL-6的血清学化验对了解生殖道衣原体感染可能无临床指导意义。
Objective To explore the changes of interleukin-2 （IL-2）, interleukin-6 （IL-6）in endocervical discharge and serum in women with genital tract infection by Chlamydia trachomatis（CT） and its significance. Methods Forty women with CT infection（ CT group） and fifteen healthy women without CT infection（ control group）were enrolled. Levels of IL-2, IL-6 in endocervieal discharge and serum were measured by radioimmunoassay（RIA）. Results The mean value of IL-2 in endocervical discharge was（20.37 ：t： 22.30） ng/ml in CT group,higher than that in control group（ P 〈 0.05）. No significant difference in IL-6 in endocervieal discharge was found between CT group and control group（ P 〉 0.05 ）. IL-2, IL-6 in serum showed no significant difference between CT group and control group（ P 〉 0.05 ）. Conclusion IL-2 may play a very important role in the pathogenesis of CT infection. The detection of IL-2, IL-6 in serum may have no instructive significance for female genital tract infection by CT.
出处
《山西医科大学学报》
CAS
2009年第7期648-650,共3页
Journal of Shanxi Medical University
基金
山西省卫生厅科技攻关计划项目(200626)
