摘要
目的检测正常人和细菌性阴道病(BV)患者治疗前后阴道局部细胞因子的变化,探讨乳杆菌活菌制剂对女性生殖道免疫的影响,为阴道微生态平衡与阴道黏膜免疫屏障的关系的研究提供一定的依据。方法用乳杆菌活菌制剂治疗BV,通过酶联免疫吸附试验法即ELISA法来检测BV患者治疗前后及正常健康妇女阴道局部细胞因子sIgA、IL-2、IL-13的水平。结果 sIgA、IL-13水平治疗前组较对照组明显升高(P<0.01),治疗后组较治疗前组水平下降(P<0.05),治疗后组较对照组水平升高(P>0.05);IL-2水平治疗前组较对照组明显降低,治疗后组较治疗前组明显升高(P<0.05),治疗后组较对照组下降(P<0.05)。结论 BV患者阴道局部免疫功能发生了改变;乳杆菌活菌制剂对BV患者阴道局部免疫具调节作用.
Objective To observe the immune cytokines levels of normal women and patients with bacterial vaginosis（BV） before and after treatment,study its role in immunological mechanisms,and lay a theoretical foundation for further study.Method The levels of cytokines sIgA,IL-2,IL-13 in the vaginal fluid of patients with bacterial vaginosis before and after treatment and of normal healthy women were evaluated by enzyme-linked immunosorbent assay method.Result The levels of sIgA and IL-13 of BV group before treatment were significantly higher than the control group（P0.01）;those of BV group after treatment were significantly lower than BV group before treatment（P0.05）;those of BV group after treatment were slightly higher than control group（P0.05）.The level of IL-2 of BV group befor treatment was significantly lower than the control group.That of BV group after treatment was significantly higher than BV group befor treatment（P0.05）,that of BV group after treatment was significantly lower than the control group（P0.05）.Conclusion The vaginal local immune function of bacterial vaginal patients have changed;Live Lactobacillus preparation can regulate the local immunity of patients with bacterial vaginosis.
出处
《中国微生态学杂志》
CAS
CSCD
2011年第9期844-845,共2页
Chinese Journal of Microecology
关键词
乳杆菌
细菌性阴道病
局部免疫
Lactobacillus
Bacterial vaginosis
Local immune
