摘要
用左心室注射石蜡油造成多发性梗塞（ＶａＤ）的动物模型，采用组织原位杂交技术及生物医学图像分析技术，测定了ＶａＤ大鼠脑内Ｐ５３ｍＲＮＡ、ＨＳＰ７０ｍＲＮＡ的表达水平。结果显示脑血疏通可通过减弱Ｐ５３ｍＲＮＡ的表达，促进ＨＳＰ７０ｍＲＮＡ表达，起到加速修复，保护脑缺血神经元的作用。
The in situ hybridization and biomedical image pattern analysis were applied in this experiment to examine P53 mRNA and HSP70 mRNA expression level in vascular dementia (VaD)of brain tissue in rats with MID produced by injecting paraffin oil to left ventricle.The result showed that Naoxie Shutong oral liquid(NXST)can improve the expression of HSP70 mRNA by diminishing the expression of P53 mRNA,leading to accelerating recovery and protecting the ischemic neuron of brain tissue.
出处
《中国实验方剂学杂志》
CAS
1998年第4期33-36,共4页
Chinese Journal of Experimental Traditional Medical Formulae
