摘要
细胞凋亡是细胞衰老、死亡过程的主要形式。最近研究发现有多种癌基因与抑癌基因参与细胞凋亡过程。因此目前认为癌基因与抑癌基因不仅控制细胞增殖，分化，而且调节细胞凋亡。细胞凋亡受阻或缺陷可能是肿瘤发生的基础之一。
poptosis.programmed cell death.is a natu-ral form of cell death characterized by activeParticipated of a cell in the process leading toits own decrepit and death. Recently.studiessuggested that apoptosis is a result from a setof discrete cellular events that are regulated bya cascade gene expression.Oncogenes and tu-mor suppressor genes are involved in this regu-lation. Apoptosis is closely related to cancer.Failure and bolckage of apoptosis in tumorcells could therefore be the fundamental impor-tance in contributing not only to the evasion ofphysiological countrols on cell numbers.butalso to the resistance both to natural defensesand to clinical therapy.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1994年第3期222-224,共3页
Progress In Biochemistry and Biophysics
关键词
细胞凋亡
癌基因
肿瘤
apoptosis.bcl-2 gene.c-mycgene.p53 gene
