摘要
以整体麻醉SD大鼠心脏冠状动脉左前降支结扎／松开作为缺血／再灌注动物模型，研究丹参注射液（SM）在加强缺血须处理（IP）的心肌保护中的作用。结果显示，IP能减轻复灌性心律失常的严重程度，缩小心肌梗死范围；SM能缩小心肌梗死范围；SM联合IP与单纯IP比较，心肌梗死范围进一步缩小；SM联合IP与单纯SM比较，心律失常严重程度减弱且心肌梗死面积进一步减小。结果表明，SM能加强IP的心肌保护作用，特别是加强IP的抗心肌梗死作用。
The role of injectio Salvia miltiorrhiza (SM) on enhancing the cardioprotective effects of ischemic preconditioning (IP) in anaesthetized rat was investigated. Results showed that IP reduced the severity of reperfusion-induced arrhythmia and limited the infarct size. SM limited the infarct size;SM+IP significantly reduced the infarct size as compared with IP alone;and significantly decreased both the infarct size and the severity of reperfusion-induced arrhythmia as compared with SM alone. These results suggested that SM can enhance the cardioprotective effects of IP.
出处
《中草药》
CAS
CSCD
北大核心
1998年第7期460-463,共4页
Chinese Traditional and Herbal Drugs
基金
卫生部
浙江省自然科学基金
浙江省中医局资助
关键词
丹参注射液
缺血预处理
心肌保护
药理
Injectio Salvia miltiorrhiza Ischemic preconditioning cardioprotective effect
