摘要
目的：观察中药清肠栓对溃疡性结肠炎大鼠实验模型的影响，探讨清肠栓的作用机制。方法：４５只模型鼠随机分为清肠栓组、ＳＡＳＰ组、安慰剂组，每组１５只。用药两周后处死。通过观察结肠粘膜损伤程度、血清ＩｇＡ、ＩｇＧ、ＩｇＭ、ＩＬ—Ⅱ及血小板粘附率，探讨清肠栓的作用机制。结果：中药清肠栓能够降低模型大鼠异常增高的血清ＩｇＧ、提高淋巴细胞产生ＩＬ—Ⅱ的能力，降低血小板粘附性，促进溃疡愈合，其效果均优于ＳＡＳＰ（Ｐ＜０．０１）。结论：中药清汤栓对溃疡性结肠炎大鼠实验模型治疗作用优于ＳＡＳＰ。其作用机制为：调节免疫、改变血液高粘状态。
object: To observe the effects of Qing Chang suppository (QCS) on the model of experimental ulcerative colitis of rats and inquire the therapeuic mechanism of QCSMethod:45 rats were used and divided into QCS treated groupSASP group and comfortable drugs group randomly.There were 15 rats of each groupThey were executed after being administered herbs two weeks.Damage degree of rats colon mucosa serum IgA、IgG、IgM、ILⅡ produced by lymphocyte decrease the throbocyte sticking rate and promote the ulcer heal up.Result: the effects of QCS are better than SASP (P<0.01).Conclusion:The effects of QCS on the model of experimental ulcerayivre colitis of rats are better than that of SASP.The mechanism of QCS is that it can modulate the rats immunity,change blood hypercogulable state,promote ulcer heal up and inflammatory tissue absorption.
出处
《河北医学》
CAS
1998年第5期1-3,共3页
Hebei Medicine
