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清肠栓对大鼠溃疡性结肠炎血清白介素-1β影响的研究 被引量：6

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摘要 目的:探讨白细胞介素-1β(IL-1β)在溃疡性结肠炎(UC)中的作用,进一步研究清肠栓治疗UC的作用机理。方法:SD大鼠56只随机分为正常组、模型组(空白组)、西药组(SASP组)、中药组(清肠栓组)共4组,每组14只。用TNBs 100 mg.kg-1灌肠建立大鼠溃疡性结肠炎模型,第3天开始,除正常组外,各组分别给予生理盐水、柳氮磺胺吡啶、清肠栓处理,至7天后处死动物。腹主动脉取血制备血清,采用ELISA法测定各组血清IL-1β的含量。结果:UC大鼠血清IL-1β含量显著升高,西药组及中药组均能降低其含量。中药组与西药组相比,P<0.01。结论:中药清肠栓可以通过降低血清IL-1β含量,调节肠道免疫,达到缓解UC的治疗目的。
作者 张涛 谢建群
机构地区 上海中医药大学附属龙华医院
出处 《江西中医学院学报》 2006年第2期57-58,共2页 Journal of Jiangxi College of Traditional Chinese Medicine
关键词 溃疡性结肠炎大鼠 白介素1Β 清肠栓
分类号 R289.5 [医药卫生—方剂学]
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参考文献9

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江西中医学院学报
2006年 第2期

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