摘要
目的分析老年高血压患者血脂与心血管系统危险的相关性,以期找到适合评估老年高血压患者心血管系统危险的血脂参数。方法选取2008年5月在解放军总医院进行健康体检、年龄60岁以上的老年人2011名,高血压诊断按照WHO/ISH高血压指南的标准,按照性别及是否患有高血压病将受试者分为4组。男性:高血压组898例,非高血压组906例;女性:高血压组97例,非高血压组110例。检测各组血压参数(收缩压、舒张压、脉压和平均动脉压)及血脂参数[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)]等指标,并采用logistic回归模型进行各血脂参数与心血管系统危险的相关分析。结果高血压组的收缩压、舒张压、脉压和平均动脉压均较同性别的对照组明显增加(P<0.01)。男性高血压组与对照组HDL-C/TG比值显著降低(P<0.05),而女性高血压组与对照组HDL-C/TG比值无统计学差异(P>0.05)。其他血脂参数各组间无明显差异。logistic回归结果显示HDL-C/TG比值与老年高血压患者心血管系统危险密切相关(P<0.05,95%CI0.723～0.978)。结论HDL-C/TG比值对预测老年高血压患者心血管系统危险更有价值。
Objective To investigate the correlation between HDL-C/TG ratio and cardiovascular risk in elderly patients with hypertension, in order to set up an evaluation criterion which may objectively assess the cardiovascular risk in elderly population. Methods A survey was carried out among 2011 subjects aged 60 or over, who received health examination in the General Hospital of PLA in May 2008. Hypertension was diagnosed by using the definition recommended by WHO/ISH. The subjects were divided into 4 groups （male hypertesion group, male control group, female hypertension group and female control group） according to their gender and with or without hypertension. The parameters of hematology （systolic pressure, diastolic pressure, pulse pressure and mean arterial pressure） and the indicators of lipidemia [total cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C）] were measured, and HDLC/TG ratio was calculated. Logistic regression analysis was used to analyze the correlation between the indicators of lipidemia and cardiovascular risk. Results In both male and female hypertension groups, systolic pressure, diastolic pressure, pulse pressure and mean arterial pressure showed significant differences compared with those of the control groups gender-wise （P〈0. 01）. HDL-C/TG ratio was significantly lower in male subjects of hypertension group than that in control group （P〈 0. 05）, while no significant difference of HDL-C/TG ratio existed between female subjects of hypertension group and control group （P〉 0. 05）. Other indicators of lipidemia showed no significant differences between hypertension group and control group. Logistic regression analysis showed that HDL-C/TG ratio was significantly correlated to the cardiovascular risk （P〈0. 05, 95%CI 0. 723-0. 978）. Conclusion HDL-C/TG ratio may be valuable to forecast the cardiovascular risk in elderly patients with hypertension.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2009年第7期878-880,共3页
Medical Journal of Chinese People's Liberation Army
基金
军队"十一五"课题基金资助项目(06MA296)
