摘要
目的探讨健康青年人在等长收缩运动（ＩＥ）时血浆内啡肽（ＥＯＰｓ）对运动心血管反应的调节作用。方法选择健康志愿者１８人（男女各９例，年龄２３．７±２．９岁），设置三种研究模型：单纯主观极量握力运动、β受体阻滞后握力运动、β受体与内啡肽受体双重阻滞后握力运动。观察指标包括亮氨酸脑啡肽（ＬＥＫ）、β内啡肽（βＥＮＤ）、强啡肽（ＤＹＮ）、心率、血压、心肌收缩时间间期以及握力。结果ＩＥ时β受体与外周组织ＬＥＫ和ＤＹＮ的释放有关；阻断β受体后血浆ＥＯＰｓ不影响ＩＥ时的心率反应；血浆ＥＯＰｓ有可能通过β受体以外的途径增强ＩＥ时心肌收缩力；ＩＥ时血浆ＬＥＫ和ＤＹＮ水平可能受其受体效应的调节。
Objective This study aimed to explore mechanism of cardiovascular regulation during isometric exercise(IE). Methods Eighteen young heathy volunteers (9 males and 9 females, aged 23.7 ± 2.9 years) were included. Exercise models were: perceived maximal handgrip IE,IE with β blocker , IE with β blocker and Naloxone.Plasma endorphins,including LEK, β-END and DYN were analysed with immunoradioassay. Systolic time intervals, blood pressure and heart rate were measured during IE. Results Peripheral release of LEK and DYN might correlate with β receptor; Endorphins had no independent effect on heart rate when β receptor was blocked during IE;Endorphins might enhance myocardial contracility during IE from a pathway, which was independent from β-receptor; Peripheral LEK and DYN levels might be regulated through their receptor response to IE. Conclusion The study provides referential indexes for rehabilitation of cardiovascular diseases.
出处
《中华物理医学杂志》
CAS
CSCD
1998年第2期105-108,共4页
Chinese Journal of Physical Medicine and Rehabilitation
基金
国家自然科学基金
关键词
内啡肽类
等长收缩运动
康复
心血管疾病
endorphins/metab
isometric exeruse
cardiovascular regulation/rehabil
