摘要
经透射电镜观察，并用形态立体计量分析法分别测量海马ＣＡ１、ＣＡ３锥体细胞上层和ＤＧ分子层突触的面密度（Ｓｖ）、数密度（Ｎｖ）以及单个突触平均面积（Ｓ）。实验结果显示人参总皂甙组的Ｓｖ和Ｎｖ较生理盐水组的分别增多４７６８±６６３％和４２５７±１６２２％（Ｐ＜０００１），而Ｓ仅在ＣＡ１区明显增多（Ｐ＜００５）。表明人参总皂甙可能主要是增加海马突触的数目，但也有增加单个突触面积的作用。上述作用是人参总皂甙诱发海马ＬＴＰ和促进大鼠学习记忆的神经物质基础。
Using microscopy and morphometry,the changes of the surface density (Sv) and the numerical density (Nv) of the synapse and the mean area of the single synapse (S) in the above layer of the pyramidal cell of hippocampal CA 1,CA 3 and the molecular layer of hippocampal dentate gyrus (DG) induced by gisenosides (GSS) were studied.The results showed that Sv and Nv of the synapse in GSS group are more 47 68±6 63% and 42 57±16 22% than those in saline group respectively (P<0 001).In CA 1,the increase of S in GSS group could be observed (P<0 05).It means that GSS could mainly elevate the number of hippocampal synapse,but GSS could also increase the mean area of the single synapse in CA 1.The changes mentioned above may be one of the morphological fundament for evoking hippocampal LTP and promoting learning and memory behavior in rat induced by GSS.
出处
《基础医学与临床》
CSCD
1998年第3期61-64,共4页
Basic and Clinical Medicine
基金
国家自然科学基金
