摘要
采用〔３Ｈ〕ＴＣＰ放射配基作海马ＮＭＤＡ受体的自显影，研究人参总皂甙在海马齿状回颗粒细胞层诱发ＬＴＰ效应和促进大鼠记忆保持能力时，海马内此受体的变化。给人参总皂甙的大鼠海马ＣＡ１、ＣＡ３和ＤＧ（ｄｅｎｔａｔｅｇｙｒｕｓ齿状回）的ＮＭＤＡ受体银粒数较给生理盐水大鼠的平均分别增多４２．８４％±２．４％，３８．５７％±３．１３％，３５．８１％±１．４６％（Ｐ＜０．０５、Ｐ＜０．０１），表明人参总皂甙在诱发海马ＬＴＰ和促进大鼠记忆行为时，可增加海马的ＮＭＤＡ受体数目和活性。
During LTP phenomenon of the granular cell layer in hippocampal dentate gyrus (DG) and the enhancement of the ability of the memory retention in rat induced by ginsenosides (GSS), the effect of GSS on the NMDA receptor in hippocampus was studied by using TCP as autoradiographical ligand. In CA 1、 CA 3 and DG, the average numbers of the silver granule of the NMDA receptor in the three GSS groups were 42 84%±2 41%,38 57%±3 13%,35 81%±1 46% respectively more than those in the three saline groups ( P< 0 05, P< 0 01). The results indicated that GSS could increase the number and activity of NMDA receptor in the hippocampus when GSS induced LTP of granular cell layer of hippocampus and promoted the ability of memory retention in rat.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1996年第6期509-512,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金
