摘要
提出了以乙酸乙酯为内标测定骨水泥中甲基丙烯酸甲酯（MMA）的释放量的项空气相色谱法。对平衡温度、平衡时间进行了试验并对顶空条件予以优化。在0．3～15．0mg·L^-1的质量浓度范围内绘制标准曲线，同时加入1．05mg·L^-1内标溶液以提高测定的准确性。结果表明：在考察的浓度范围内线性关系良好，检出限（3S／N）为94．5μg·L^-1。样品中加入1．05mg·L^-1甲基丙烯酸甲酯标准溶液进行回收试验，平行测定5次，所得回收率为97．6％～101．8％，相对标准偏差小于2％。在模拟手术条件下，骨水泥中的甲基丙烯酸甲酯在20min以后释放总量达到平衡。
Head-space GC determination of methyl methacrylate （MMA） released from bone cement was proposed and conditions of head-space, including time and temperature for equilibrium, were studied and optimized. Standard curve in the mass concentration range of 0. 3--15. 0 mg·L^-1 was prepared with addition of 1.05 mg·L^-1 of ethylacetate as internal standard to improve precision of the determination. Linearity was attained in the concentration range tested. Detection limit （3S/N） of the method found was 94. 5 μg·L^-1. Test for recovery was made by addition of 1.05 mg·L^-1 of standard MMA for 5 determinations, values of recovery found were ranged from 97. 6% to 101. 8% with RSD＇s （n=5） less than 2%. Equilibrium of release of MMA was attained after 20 min in the simulated condition of orthopaedic operation.
出处
《理化检验（化学分册）》
CAS
CSCD
北大核心
2009年第6期707-709,共3页
Physical Testing and Chemical Analysis(Part B:Chemical Analysis)
基金
南京医科大学科技发展基金8612
关键词
顶空气相色谱法
甲基丙烯酸甲酯
骨水泥
释放量
内标
Head-space gas chromatography
Methyl methacrylate
Bone cement
Releasing amount
Internal standard
