摘要
目的：调查我国某大型综合性医院呼吸科住院患者抗生素的使用情况，以指导临床合理用药。方法：采用临床流行病学回顾性调查方法，收集2003年1月-2007年12月我国某大型综合性医院呼吸科所有住院感染患者的临床资料，统计分析感染性疾病种类、抗生素消耗量及相互间的关系。结果：该院呼吸科病房住院患者以下呼吸道感染为主，其他所占比例相对较少；抗生素用量最大为头孢菌素类／β内酰胺酶抑制剂，其次为青霉素类／β内酰胺酶抑制剂，碳青霉烯类及多肽类稳定在较低的水平；上呼吸道与下呼吸道感染与各类抗生素药物的限定日剂量频度存在差别；阿莫西林类药物利用指数值逐年升高，其他类抗生素药物利用指数值变化较为平稳。结论：该大型综合性医院呼吸科在临床经验性选择抗生素、抗生素使用策略方面基本合理，有效降低了病原菌的耐药水平。
Objective：To investigate the characteristics of antibiotic drug use in the respiratory department of a large general hospital for the clinical therapy. Methods： A retrospective cohort study was conducted on the infection patients from Jan. 2003 to Dec. 2007 in the respiratory department of Chinese PLA general hospital. The change of the infectious disease distribution, the antibiotics con- sumption, and the relation between disease and drug consumption were analyzed. Results ： （ 1 ） The lower respiratory tract infection was the major disease in the patients of the respiratory department. （2） The antibiotics of the consumption in respiratory department were Cephalosporin/β- lactamase inhibitors, Pennicllins/β - lactamase inhibitors in sequence, and the Carbapenem and polypeptide antibiotics remained at a relatively low level. （3） The defined daily doses of antibiotics were different between the lower and upper respiratory tract infection. （4）The drug utilization index of amoxicillin group antibiotics was increased year by year and no significant change was found in other kinds of antibiotics. Conclusion ： Significant changes were found in the antibiotics use among the patients within respirator department of this large general hospital, and that should be paid more attention in the clinical work.
出处
《药学实践杂志》
CAS
2009年第3期228-230,235,共4页
Journal of Pharmaceutical Practice
关键词
感染性疾病
抗生素
每日约定剂量
经验治疗
infectious diseases
antibiotics
defined daily dose
empiric therapy
