摘要
目的比较重症监护病房(ICU)与非ICU肺炎克雷伯菌的耐药性,了解临床肺炎克雷伯菌感染的药敏变化,分析ICU与非ICU肺炎克雷伯菌的耐药性差异及原因,为临床合理应用抗菌药物提供科学依据。方法对2011年1月-2012年6月临床标本中分离的肺炎克雷伯菌129株进行比较分析,用VITEK-32微生物分析系统进行病原菌鉴定,药敏试验K-B纸片法,应用SPSS19.0对临床分离细菌的药敏试验结果进行统计分析。结果共分离出肺炎克雷伯菌129株,其中ICU分离24株占23.40%,非ICU分离105株占76.60%;ICU中肺炎克雷伯菌的耐药率明显高于非ICU,ICU对头孢呋肟、头孢克洛、氨苄西林耐药率均为100.0%,而非ICU分别为49.52%、35.24%、96.19%。结论 ICU分离的肺炎克雷伯菌对9种抗菌药物耐药率明显高于非ICU,应用抗菌药物治疗该菌感染时,应注意加强监测临床感染菌的药敏变化,有针对性地选用敏感性强的抗菌药物,有效控制和减缓细菌耐药性的发生。
OBJECTIVE To compare drug resistance of Klebsiella pneumoniae in the intensive care unit （ICU） and in non-ICU, understand susceptibility changes in clinical K, pneumoniae infection, and analyze the differences of K. pneumoniae resistance in the ICU and in non-ICU and the according causes, so as to provide scientific basis for clinical rational use of antibiotics. METHODS A total of 129 strains of K. pneumoniae isolated from clinical speci-mens in our hospital from Jan. 2011 to Jun. 2012 were compared and analyzed, using VITEK-32 microbiology analysis system for pathogen identification, the drug sensitive test was performed with the K-B disk method, and SPSS 19.0 was used for statistical analysis of results of drug susceptibility test on clinical isolated bacteria. RESULTS A total of 129 strains of K. pneumonia were isolated, among which, 24 strains were isolated from ICU accounting for 23. 40%, 105 strains isolated from non-ICU accounted for 76.60%. The resistance rate of K. pneu- monia in ICU was significantly higher than that in non-ICU. The resistance rates to Cefuroxime, Cefaclor, and Ampicillin were all 100.0% in ICU, while 49.52%, 35.24%, and 96.19% in non-ICU. CONCLUSION The drug resistance rate of K. pneumoniae isolated in ICU to 9 kinds of antibacterial drugs is significantly higher than that in non-ICU. For application of antibacterial drugs in the treatment of such bacterial infection, more attention should be paid to strengthening the monitoring of susceptibility changes in clinical infectious bacteria, targeted selection of antibacterial drugs with high sensitivity, in order to effective control and reduce the incidence of bacterial drug resistance.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第23期5815-5817,共3页
Chinese Journal of Nosocomiology
基金
贵州省科技厅联合基金项目(黔科合LG字[2012]077)
