摘要
目的：探讨ｋｉ－６７抗原表达与胃癌的恶性生物学行为，特别是与远隔脏器转移行为的关系。方法：应用ＤＡＫＯ公司新推出的兔抗人ｋｉ－６７多克隆抗体，对５６例胃癌的常规病理切片进行ＡＢＣ免疫组化检测。结果：ｋｉ－６７抗原表达量与胃癌组织学类型、分化程度、生长方式、胃壁浸润深度以及区域淋巴结转移无明显相关（Ｐ＞０．０５）。与胃癌的肝、卵巢、肾上腺等远隔脏器的转移呈明显正相关（Ｐ＜０．００５）。ｋｉ－６７抗原表达量与胃癌组织的ＤＮＡ异倍体呈明显正相关（Ｐ＜０．０５）。结论：ｋｉ－６７抗原作为一个代表增殖活性的肿瘤标志，其过量表达与胃癌细胞的恶性生物学行为，特别是与远隔脏器转移行为密切相关。
Objective:This paper was designed to investigate the relationship between expression of ki 67 antigen and pathobiological behaviour of gastric cancer. Methods: We fixed 56 gastric cancer specimens routinely in formalin and embeded them with paraffin. They were studied with a new monocolonal antibody to ki 67 antigen by ABC immunohistochemical method. Results: The expression of ki 67 antigen was significantly related to the distant metastases from gastric cancer to the liver, ovary and adrenal (P<0 05); but not related to the histological differentiation and the metastases of local lymph nodes (P>0 05). The expression of ki 67 was significantly related to the DNA anueploid pattern. Conclusions: The overexpression of ki 67 could be used as an objective marker proliferative activity in gastric cancer tissues, which was closely related to the malignant biological behaviour of gastric cancer, especially in distal metastases. It would be of value to accurate evaluation of the prognosis for gastric cancer and to the determination of high risk in its metastases to distant organs.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1998年第3期241-242,246,共3页
Journal of China Medical University
基金
国家自然科学基金
