摘要
目的探讨Ki-67抗原表达与肾细胞癌临床病理的关系。方法采用免疫组化方法,应用Ki-67单克隆抗体MIB1研究肾癌组织中Ki-67抗原表达及与肾癌临床病理的联系。结果正常肾组织无Ki-67抗原表达。肾癌组织Ki-67抗原表达在肾癌临床分期、病理分级间有显著性差异(P<0.01)。Ki-67指数<9.5%者术后生存率明显高于Ki-67指数>9.5%者(P<0.01)。结论 Ki-67抗原表达相关于肾癌的恶性度、预后。Ki-67指数可作为判断肾癌恶性度、预后的指标。
Objective To study the expression of Ki-67 antigen in renal cell carcinoma (RCC) and its relation to clinical pathology. Methods Using immunohistochemical method and monoclonal antibody MIBl,the expression of Ki-67 antigen in RCC and their relation to the clinical pathology were investigated. Results There was no Ki-67 antigen expression in normal renal tissue. There were significant variance of Ki-67 antigen expression among clinical stage and pathologic grade (P<0. 01). The living rate after opera-tion in Ki-67 index<9.5% group was obviously higher than those in Ki-67 index>9.5% group (P<0. 01). Conclusion The expression of Ki-67 antigen was related with malignant behavior and prognoss of RCC.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1998年第6期508-509,共2页
Chinese Journal of Experimental Surgery
