摘要
制备掩盖头孢呋辛酯苦味的混合物,并用其进一步制成头孢呋辛酯混悬颗粒剂。以Carbopol为载体材料,用溶剂挥发法制备掩味混合物;以口感有无苦味为评价指标,结合体外溶出实验,找出最佳处方;并对最终处方进行稳定性考察。以Carbopo l934 PNF为载体材料制备的混合物可以掩盖头孢呋辛酯药物的苦味,且体外释放及稳定性均符合要求,其制成的颗粒剂质量合格。
In order to mask the bitterness of cefuroxime and prepare its granules, with carbopol as the main materials, the masking complex was prepared. The release of pravastain from it was determined both in oral cavity and in vitro, and then review the stability of the ultimate formula. The complex made by Carbopol 934 PNF can mask the bitterness of cefuroxime, and it＇ s release invitro and stability both meet the requirement, and the formulation of the granules is reasonable.
出处
《河北化工》
2009年第6期16-17,共2页
Hebei Chemical Industry
