摘要
目的对比观察非手术与手术治疗肝硬化并脾功能亢进患者肝功能损害的临床疗效和安全性。方法将58例肝硬化并脾功能亢进患者分为非手术组（34例）和手术组（24例）。并对两组患者治疗前后临床表现、肝功能[丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、总胆红素（TBil）、直接胆红素（DBil）]和不良反应进行比较，探讨非手术与手术治疗肝硬化脾功能亢进患者肝功能损害的疗效和安全性。结果两组治疗后1周和2周时，ALT和AST均显著降低（P〈0．01，P〈0．05）；与非手术组比较，手术组治疗后1周和2周时，ALT、AST降低显著优于非手术组（P〈0．01，P〈0．05）。两种治疗方法均能改善患者的临床症状，缓解并发症，且手术治疗较非手术治疗不良反应少。结论手术和非手术治疗均能显著改善肝硬化并脾功能亢进患者肝功能损害，且手术治疗改善肝功能疗效显著，不良反应较少，安全性较好。
Objective To observe clinical efficacy and safety of nonoperative and operative therapies in liver dysfunction of patients with liver cirrhosis and hypersplenism. Methods Fifty-eight cases of liver cirrhosis and hypersplenism were divided into nonoperative group （n = 34） and operative group （n = 24）. Clinical data including clinical manifestations, liver function consisted of alanine aminotransferase （ALT） , aspartate aminotransferase （AST） , total bilirubin （ TBil ） and direct bilirubin （ DBil ） was ana- lyzed in both groups before and after nonoperative or operative therapies. Adverse reactions were also evaluated in both two groups. Clinical efficacy and safety of nonoperative and operative therapies in liver dysfunction of patients with liver cirrhosis and hypersplenism were evaluated by comparing the clinical data and adverse reactions in both groups. Results Serum ALT and AST were significantly decreased at 1 week and 2 weeks in both groups. At the time points of one week and two week after therapy, serum AST and ALT levels were more markedly reduced in operative group than in nonoperative group （ P 〈 0.01 and P 〈0.05 ,respectively）. The two therapies relieve both clinical symptoms and complications of patients, and less adverse reactions occurred in operative therapy group than in nonoperative therapy group. Conclusion Both operative and uonoperative therapies can significantly improve liver function of patients with liver cirrhosis and hypersplenism, however, operative therapy has significantly advantage than nonoperative therapy in efficacy and security with less adverse reactions.
出处
《临床内科杂志》
CAS
2009年第6期409-411,共3页
Journal of Clinical Internal Medicine
关键词
肝硬化
脾功能亢进
肝功能损害
Liver cirrhosis
Hypersplenism
Liver dysfunction
Comparative study
