期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

大肠癌肝转移动物模型的研究进展 被引量：4

Animal models of colorectal cancer and liver metastases
原文传递
导出
摘要 肝脏是大肠癌转移的最常见器官。为更好地研究大肠癌肝转移，建立和选择合适的大肠癌肝转移模型十分重要。在此就大肠癌肝转移模型：原位植入模型，经脾接种癌细胞，门静脉内注射，直接将癌细胞种植到肝脏的相关研究进展进行综述。 The liver is the most common site of distant metastasis of colorectal cancer. In order to study colorectal cancer metastasis to the liver, establishing and choosing appropriate mouse model is crucially iraportant. In this review, we mainly discuss the mouse models of colorectal cancer and liver metastases： Tumor fragments or cancer cells orthotopic transplant to cotoncecal part, injecting cancer cells into the spleen,portal injection of cancer cells,colorectal cancer implantation to the subcapsular of the liver.
作者 杨荣娇 何兴祥
机构地区 广东药学院临床医学院
出处 《国际外科学杂志》 2009年第5期316-319,共4页 International Journal of Surgery
基金 广东省自然科学基金项目（No.7101731） 中山市科学技术局科技计划项目（No.2003A185） 广东省科学技术厅科技计划项目（No.2008A030201001）
关键词 大肠癌 肝转移 动物模型 colorectal cancer liver metastases mouse models
分类号 R735.3 [医药卫生—肿瘤] R-332 [医药卫生]
  • 相关文献

参考文献20

  • 1Talmadge JE,Singh RK,Fidler LI,et al.Murine models to evaluate novel and conventional therapeutic strategies for cancer[J].Am J Pathol,2008,172(2):358-366.
  • 2Heijstek MW,Kranenburg O,Berel Rinkes IH.Mouse models of colorectal cancer and liver metastases[J].Dig Surg,2005,22(1-2):16-25.
  • 3甘伙烨,何兴祥,邹湘才,黄世章,廖德贵,苏杭.盲肠造疝原位接种瘤块法建立小鼠大肠癌肝转移模型[J].广东医学,2007,28(6):855-857. 被引量：15
  • 4Céspedes Maria V,Espina C,García-Cabezas MA,et al.Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites[J].Am J Pathol,2007,170(3):1077-1085.
  • 5Espina C,Cépedes MV,García-Cabezas M,et al.A critical role for Racl in tumor progression of human colorectal adenocarcinoma cells[J].Am J Pathol,2008,172 (1):156-166.
  • 6Kuwai T,Nakamura T,Sun-Jin Kim,et al.Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotepic tumors[J].Am J Pathol,2008,172(2):358-66.
  • 7Gno XN,Rajput A,Rose R,et al.Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model[J].Cancer Res,2007,67(12):5851-5858.
  • 8Nakamura K,Taniguchi T,Funnhashi Y,et al.Effects of ER37328 on primary tumor,liver metastasis,and life span in a mutine colon 38 orthotopic transplantation model[J].Molecular Cancer Therapeutics,2003,2 (1):59-64.
  • 9Murata K,Moriyama M.Iseleucine,an essential amino acid,prevents liver metastases of colon cancer by antiangiogenesis[J].Cancer Res,2007,67(7),3263-3268.
  • 10Hiraoka K,Kimura T,Logg CR,et al.Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model[J].Cancer Res,2007,67(11):5345-5353.

二级参考文献9

  • 1HORIG H,WAINSTEIN A,LONG L,et al.A New Mouse Model for Evaluating the Immunotherapy of Human Colorectal Cancer[J].Can Res,2001,61:8 520-8 526.
  • 2SADAHIRO S,SUZUKI T,ISHIKAWA K,et al.Estimation of the Time of Pulmonary Metastasis in Colorectal Cancer Patients with Isolated Synchronous Liver Metastasis[J].Jpn J Clin Oncol,2005,35(1):18 -22.
  • 3MARTINET O,ERMEKOVA V,QIAO J Q,et al.Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand:Long -term remission of liver metastases in a mouse model[J].J Nat Can Ins,2000,92(11):931 -936.
  • 4MARZOLA P,DEGRASSI A,CALDERAN L,et al.In vivo assessment of antiangiogenic activity of SU6668 in an experimental colon carcinoma model[J].Clin Can Res,2004,10:739 -750.
  • 5WANG Z,HUBBARD G B,PATHAK S,et al.In vivo opossum xenograft model for cancer research[J].Can Res,2003,63(19):6 121 -6 124.
  • 6黄平.大肠癌肝转移模型研究进展[J].实用肿瘤杂志,1998,13(1):60-63. 被引量：7
  • 7许勤,吴文溪,马利民,王学浩.小鼠结肠腺癌肝转移模型的建立[J].实用癌症杂志,2000,15(5):456-457. 被引量：32
  • 8陈路,王平治,兰澜.建立裸小鼠大肠癌肝脏微转移模型的方法研究[J].中国现代普通外科进展,2003,6(1):18-21. 被引量：9
  • 9李宁,段广才,李苏宜,郗园林.实验性小鼠前胃癌肝转移模型的建立[J].东南大学学报（医学版）,2003,22(5):313-315. 被引量：7

共引文献14

同被引文献88

  • 1张杰,姚明,闫明霞,徐冰,刘蕾,孔韩卫,罗玉柱.小鼠结肠癌高转移模型体内筛选和建立[J].实验动物与比较医学,2006,26(3):134-139. 被引量：2
  • 2常俊峰,李明,李虎林,等.联合检测血清肿瘤标志物在结直肠癌诊断和预后判断中的应用[J].检验医学与临床,2014,11(8):1082.
  • 3Muzny DM, Bainbridge MN, Chang K, et al. Comprehensive too-lecular characterization of human colon and rectal cancer[ J]. Na- ture, 2012, 487(7407): 330-337.
  • 4Tone LA, Bray F, Siegel RL, et al. Global cancer statistics [ Jl. CA Cancer J Clin, 2011, 61(2): 69-90.
  • 5Courtney RJ, Paul CL, Carey ML, et al. A population-based cross- sectionaX study of colorectal cancer screening practices of first-de- gree relatives of colorectal cancer patients [ J 1. BMC Cancer, 2013, 13(1): 1-11.
  • 6Dahan L, Norguet E, Etienne- Grimaldi MC, et al. Pharmacogenet- ic profiling and cetuximab outcome in patients with advanced color- ectal cancer[J]. BMC Cancer, 2011, 11(1) : 496.
  • 7Kostova E, Slaninka-Miceska M, Labacevski N, et al. Expression of matrix metalloproteinases 2,7 and 9 in patients with colorectal cancer[ J~. Vojnosanit Pregl, 2014, 71 ( 1 ) : 52-59.
  • 8Zhang S, Chen Y, Zhu Z, et al. Differential expression of carbohy- drate antigen 19-9 in human colorectal cancer: a comparison with colon and rectal cancers[ J]. Mol Clin Oncol, 2013, 1 (6) : 1072- 1078.
  • 9Zhong W, Yu Zhong, Zhan J, et al. Association of Serum Levels of CEA, CA199, CA125, CYFRA21-1 and CA72-4 and Disease Characteristics in Colorectal Cancer [ J]. Pathol Oncol Res, 2015, 21(1) : 83-95.
  • 10Chan CC, Fan CW, Kuo YB, et al. Multiple serological biomarkers for eolorectal cancer detection [Jl- Int J Caneer, 2010, 126(7) : 1683-1690.

引证文献4

二级引证文献7

国际外科学杂志
2009年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部