摘要
目的探讨经鼻内镜手术治疗嗅神经母细胞瘤的可行性及疗效。方法对1994年8月～2008年6月30例经病理证实为嗅神经母细胞瘤的患者资料进行回顾性分析,对其手术方式和疗效进行对比研究。其中男20例,女10例,年龄12～77岁。依据Kadish分期,A期3例、B期10例、C期17例。结果随访时间3～97个月,中位随访时间31个月。其中鼻内镜入路16例,内镜经鼻联合经颅入路3例,鼻侧切开或联合经颅入路11例。应用Kaplan-Meier法按分期对不同的手术入路分别计算生存率,经内镜鼻或联合经颅入路患者5年总体生存率为70.1%,无瘤生存率为54.9%;鼻侧切开或联合经颅入路患者分别为61.4%和30.3%。结论鼻内镜手术是治疗鼻腔、鼻窦嗅神经母细胞瘤的有效方法。
OBJECTIVE To explore feasibility and therapeutic efficacy of transnasal endoscopic resection and craniofacial resection through an external approach for olfactory neuroblastoma （ONB）. METHODS Thirty patients （twenty men and ten women） ranging in age from 12-77 years with ONB treated between 1994 and 2008 were reviewed retrospectively. All thirty cases were determined by the Kadish clinical stage, three cases with stage A, ten cases with stage B and seventeen with stage C. RESULTS The patients were followed up for 3-97 months, the median follow-up time was 31 month. Sixteen patients underwent endoscopic surgery,three patients treated by combined endoscope and transcranial surgery and eleven patients treated by craniofacial resection through an external approach. The 5-year overall survival rate and the 5-year disease free survival rate of patients with transnasal endoscopic resection were 70.1% and 54.9%; for patients with craniofacial resection through an external approach, rates were 61.4% and 30.3% respectively. CONCLUSION the endoscopic approach surgery appears to be the method of choice for removing Olfactory neuroblastoma tissue as with external approaches.
出处
《中国耳鼻咽喉头颈外科》
北大核心
2009年第5期247-250,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
关键词
内窥镜检查
成感觉神经细胞瘤
嗅觉
耳鼻喉外科手术
Endoscopy
Esthesioneuroblastoma,Olfactory
Otorhinolaryngologic Surgical Procedures
