摘要
对急、慢性精神分裂症病人99例和正常对照者51人的红细胞SOD、GPX及CAT活性进行了对比研究。结果发现,病人红细胞SOD活性与正常人比较具有非常显著意义的升高(t=3.9～7.46,P<0.001),急性组女性病人红细胞SOD活性显著高于男性病人(t=3.80,P<0.001)。各组间的GPX、CAT活性则无明显差异(P>0.05)。研究发现精神分裂症病人红细胞SOD活性改变与BPRS总分呈正相关(γ=0.588,P<0.05)。本研究结果表明,精神分裂症病人红细胞SOD活性明显增高,提示氧自由基在精神分裂症病因学或其精神病理过程中可能具有一定的作用。
A comparative study of the activities'of superoxide dismutase (SOD),glutathione peroxidase (GPX) and catalase (CAT) in erythroete was carried out in 99 DSM-III-R-schizophrenic in patients including 49 cases in acute phase and 50 cases in chronic phase,and the values were compared with those of 51 normal subjects.The results indicated that the activity of SOD in total patient group was higher significantly than that of control group,t=3.90~7.46,P<0.001.The SOD activity of the female group (n=25),was distinctly elevated than that of male group (n=25) with P value less than 0.001.No significant difference in activities of GPX and CAT between the patient group and control group was found.A positive correlation between SOD activity and total BPRS scores was found (r=0.588,P< 0.05).the distinct increase in SOD activity in schizoprenic patients suggest that oxygen free radicals play a role in the pathogenesis of schizophrenia.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1990年第2期83-86,共4页
Medical Journal of Chinese People's Liberation Army
