摘要
研究目的探讨脂质过氧化作用及其抗氧化酶防御系统在精神分裂症的发生与发展过程中的作用。研究背景近年来,国外初步研究发现精神分裂症患者的自由基及其抗氧化酶防御系统有显著改变,目前这方面的研究国内报道较少。研究方法对66例精神分裂症患者和36例正常人均抽取空腹静脉血,分离血清,用荧光法测定其过氧化脂质(LPO)含量和谷胱甘肽过氧化物酶(GPX)活性,用Pvrogallol—NBT法测定超氧化物歧化酶(SOD)活性,对比分析三项指标的变化及其与病期的关系。统计学处理采用t检验及相关分析。结果精神分裂症患者血清LPO含量和SOD活性均明显高于正常人(P<0.05,P<0.01),GPX活性明显低于正常人(P<0.01);LPO与病期呈正相关(r=0.34,P<0.01),SOD与病期呈负相关(r=-0.359,P<0.01),GPX与病期无显著相关(r=-0.183,P>0.05)。结论精神分裂症患者体内自由基产生增加,由此导致脂质过氧化作用增强,且随病期延长进一步加重。
Objective To search for the action of lipidperoxidation that free result in the occurence anddevelopment of schizophrenea. Background Recentely,oversea initial studyfound that there are significant changes in the freeradical and enzymes of the antioxidant defens sys—tem in schizophrenic patients.At present,domes·tic reports on this field are rare. Methods The fasting venous blood weredrawn,serum seperated immediately.The levels ofserum LPO and GPX were determined byfluorescence spectrophotometry and SOD activitywere measured by pyrogallol——NBT method in 66schizophrenic patients and 36 normal persons,thechanges of three parameters and their relations tostadia were analysed comparatively.The statistical of detcrmination results was.treaded with t-test and correlation analyes. Results Compared with the normal persons,both the levels of serum LP0 and SOD were obvi.ously higher(P<0.05,P<0.01)and GPX low-er(P<O.O 1)in the patients,LPO contents were positivefy correlation to statia f r。二O.34 1·P<O.0 1),SOD activity negatively(r。--0.359,P<0.01),and GPX not obviously(r=-0.183,P>0.05). Conclusion Lipid peroxidation that free rad·ical resuer in increased is in schizOphrennic pa—tients,and the longer statia was,the more seriousit was.
出处
《新乡医学院学报》
CAS
1993年第4期291-294,共4页
Journal of Xinxiang Medical University
关键词
精神分裂症
自由基
过氧化脂质
schizophrenia
free radical
lipid peroxide
surperoxide dismutase
glutathione peroxidase
