摘要
目的:制备右旋布洛芬糖浆,并建立其质量控制方法。方法:以右旋布洛芬为主药制备糖浆;采用高效液相色谱法测定其中主药的含量。结果:所制制剂为淡黄色至黄棕色澄明黏稠液体,检查、鉴别项均符合2005年版《中国药典》中的相关规定。右旋布洛芬检测浓度的线性范围为0.1006～0.5028mg.mL-1(r=0.9999),平均回收率为99.65%(RSD=0.64%)。结论:该制剂制备方法简便可行,质量可控。
OBJECTIVE： To prepare Dexibuprofen Syrup and establish a method for its quality control. METHODS： Dexibuprofen Syrup was prepared with dexibuprofen as main ingredient and the content of dexibuprofen was determined by HPLC. RESULTS： The preparation appeared as yellowish or yellowish-brown sticky liquid and its property was in line with the standard specified in Chinese Pharmacopeia （2005 Edition）. The linear range of dexibuprofen was 0.100 6-0. 502 8 mg·mL^-1 （r = 0.999 9） and its average recovery rate was 99.65% （RSD = 0.64%） . CONCLUSION： This preparation is simple and feasible in preparation technology and controllable in quality.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第16期1242-1243,共2页
China Pharmacy
