摘要
微针给药作为新型的透皮给药方式,能够穿透角质层而不触及神经,集皮下注射和透皮贴剂优点于一体,不仅无痛微创,而且药物吸收效率高,是未来重要的给药方式。文章基于有限元分析原理,提出了一种仿真优化-实验验证的微针设计制造策略,建立了微针的力学性能分析模型和药物释放性能分析模型,分析了不同结构参数对微针机械性能和释放性能的影响,构建了关键结构参数与微针性能之间的映射关系。在此基础上,实验部分采用模具法结合紫外光聚合法制备了优化后的聚乙二醇二丙烯酸酯/聚乙烯吡咯烷酮(PEGDA/PVP)可溶性微针,制得针底直径为300μm、针高为600μm、基底厚度为2 mm的20×20微针阵列。所制备的微针形貌完整,具有良好的柔韧性和皮肤贴合性,同时展现出较强的机械强度。以罗丹明B(RhB)为模型药物,开展释放实验,结果表明,聚合物微针能够实现药物的缓慢持续释放。该研究不仅制备了一种新型微针,更构建了一套从理论仿真到实验验证的完整评价体系,为微针在临床药物递送中的应用提供了实验与理论支撑。
As a novel transdermal drug delivery method,microneedle-based administration can penetrate the stratum corneum without reaching nerve endings.It combines the advantages of subcutaneous injection and transdermal patches,offering a painless,minimally invasive approach with high drug absorption efficiency,and holds great promise for future drug delivery applications.In the study,finite element analysis(FEA)was employed to establish mechanical performance and drug release models for microneedles.The influence of various structural parameters on both mechanical strength and drug release behavior was systematically analyzed.Experimentally,dissolvable microneedles made of polyethylene glycol diacrylate/polyvinylpyrrolidone(PEGDA/PVP)were fabricated using mold casting and UV photopolymerization methods.A 20×20 microneedle array was successfully prepared,with each needle featuring a base diameter of 300μm,a height of 600μm,and a substrate thickness of 2 mm.The resulting microneedles demonstrated intact morphology,good flexibility,excellent skin conformity,and robust mechanical strength.Rhodamine B(RhB)was used as a model drug to verify the drug release behavior,and the results confirmed the ability of the polymer microneedles to achieve sustained release.In conclusion,a novel PEGDA-based dissolvable microneedle drug delivery system was developed,which effectively penetrates the skin's stratum corneum and exhibits good biocompatibility,providing both experimental and theoretical support for clinical applications of microneedle technology.
作者
Muhammad Shahzeb
覃林
陈君儒
王竹卿
黄舒
Muhammad Shahzeb;QIN Lin;CHEN Junru;WANG Zhuqing;HUANG Shu(College of Mechanical Engineering,Sichuan University,Chengdu 610000,China)
出处
《传感器世界》
2025年第11期32-38,共7页
Sensor World
关键词
微针
可溶性
有限元分析
药物递送
microneedle
dissolvable
finite element analysis
drug delivery
