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丹参防治全胃肠外营养致肝损害相关蛋白质组学初步研究 被引量:1

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摘要 目的:寻找与丹参防治全胃肠外营养肝损害相关的蛋白质。方法:选取需要全胃肠外营养的患者,分别给予静脉全胃肠外营养(对照组)及全胃肠外营养+丹参(实验组)。治疗15d后收集两组血清,用二维凝胶电泳分离血清蛋白质获得差异表达蛋白质,采用基质辅助激光解吸电离飞行时间质谱和数据库分析鉴定两组差异表达蛋白质。结果:发现5个具有明显表达差异的蛋白质斑点,经鉴定确定为血清清蛋白前体、接联球蛋白、免疫球蛋白κ链C区、补体C4-B前体和血清铁传递蛋白前体。结论:丹参可能通过上调或下调上述蛋白质的表达,参与防治全胃肠外营养对肝脏的损害。
出处 《山东中医药大学学报》 2009年第3期209-210,共2页 Journal of Shandong University of Traditional Chinese Medicine
基金 广州市卫生局中医科研资助项目(编号:2007A34)
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参考文献7

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二级参考文献17

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