摘要
以光镜观察了５例胃肠瘘行全肠外营养（ｔｏｔａｌ ｐａｒｅｎｔｅｒａｌｎｕｔｒｉｔｉｏｎ，ＴＰＮ）支持治疗之肝活检标本。肝之基本病变为淤胆，最先见于胞浆，继而毛细胆管和小胆管；其他病变，如肝细胞变性、枯氏细胞增生、汇管区扩大和纤维及小胆管增生，以及小胆管周围炎等，均为长期淤胆之结果。临床有些酶异常先于病理改变；发病与ＴＰＮ用量、使用时间及营养配方有关。
The liver biopsy specimens were obtained from 5 cases with total parenteral nutrition (TPN) for gastrointestinal fistula and examined by light microscope.The principal pathological change of the liver was the stasis of bile,being firstly seen in the cytoplasm and then in the capillary bile ducts and biliary canaliculi,and the other changes were degeneratin of liver cells,hyperplasia of Kupffer's cells,enlargement of portal area,hyperplasia of fibers as well as biliary canaliculi,peribiliary canaliculitis,etc which were all the results from the bile stasis for a long duration.Clinically,some enzymatic abnormalities presented prior to the pathological changes.The occurrence of the liver damage is considered to be relevant to the quantity,duration and the prescription of nutritious material,etc of total parenteral nutrition.By referring to literatures,the mechanism,prophylaxis and treatment of liver damage occurring in TPN were discussed.
出处
《诊断病理学杂志》
CSCD
1995年第3期142-143,共2页
Chinese Journal of Diagnostic Pathology
关键词
全肠外营养
肝损害
Total parenteral nutrition
Bile stasis
Liver damage
Gastrointestinal fistula
