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TGF-β_1、IFN-γ和iNOS在实验性自身免疫性脑脊髓炎中枢神经系统的表达 被引量：3

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摘要 将大鼠随机分为4组,A组注射新鲜豚鼠脑脊髓匀浆(GPSCH)和完全弗氏佐剂(CFA)及百日咳杆菌;B组注射GPSCH和CFA;C组注射牛脊髓和CFA及百日咳杆菌;D组注射生理盐水和CFA。免疫组化方法检测各组动物中枢神经系统组织中TGF-β1、IFN-γ、iNOS的表达情况。结果发现,与D组比较,A、B组大鼠脑和脊髓中TGF-β1表达明显减少,IFN-γ、iNOS表达明显增加;IFN-γ增加以A组最明显,A和B组中iNOS增加水平相似。认为TGF-β1可能作为一种内源性保护因子在实验性自身免疫性脑脊髓炎(EAE)的恢复中起作用,EAE发作时,中枢神经系统中IFN-γ、iNOS表达增加,这两者可能在EAE的发病中起重要作用。
作者 徐竹 楚兰
机构地区 贵阳医学院附属医院
出处 《山东医药》 CAS 北大核心 2009年第20期39-41,共3页 Shandong Medical Journal
基金 贵州省优秀科技教育人才省长专项资金项目[黔省合专字(2005)227号]。
关键词 脑脊髓炎 实验性自身免疫性 百日咳杆菌 转化生长因子Β
分类号 R322.81 [医药卫生—人体解剖和组织胚胎学]
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参考文献9

  • 1Prud'homme GJ,Piccirillo CA.The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases[J].J Autoimmun,2000,14(1):23-42.
  • 2Sun D.Enhanced interferon-gamma-induced Ⅰa-antigen expression by glial cells after previous exposure to this cytokine[J].J Neuroimmunol,1991,34(2-3):205-214.
  • 3Link J,Sderstrm M,Olsson T,et al.Increased transforming growth factor-beta,interleukin-4,and interferon-gamma in multiple sclerosis[J].Ann Neurol,1994,36(3):379-386.
  • 4Simmons RD,Willenborg DO.Direction injection of cytokines into the spinal cord causes autoimmune encephalomyelitis-like imflammation[J].J Neurol Sci,1990,100(1-2):37-42.
  • 5Issazadeh S,Navikas V,Schaub M,et al.Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo[J].J Immunol,1998,161(3):1104-1112.
  • 6Heiss LN,Lancaster JR Jr,Corbett JA,et al.Epithelial autotoxicity of nitric oxide:role in the respiratory cytopathology of pertussis[J].Proc Natl Acad Sci USA,1994,91(1):267-270.
  • 7Laszlo F,Whittle BJ,Evans SM,et al.Association of microvascular leakage with induction of nitric oxide synthase:effects of nitric oxide synthase inhibitors in various organs[J].Eur J Pharmacol,1995,283(1-3):47-53.
  • 8Boje KM.Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis[J].Brain Res,1996,720(1-2):75-83.
  • 9Zhao W,Tilton RG,Corbett JA,et al.Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine,an inhibitor of nitric oxide synthase[J].J Neuroimmunol,1996,64(2):123-133.

同被引文献22

  • 1辛晋敏,马存根,梁丽云,马太花,尉杰忠.细胞间黏附分子-1在实验性自身免疫性脑脊髓炎大鼠中表达的动态变化及作用[J].中国神经免疫学和神经病学杂志,2006,13(2):77-81. 被引量：10
  • 2徐全刚,王晓辉,任晓暾,黄德晖,吴卫平.干扰素β-1b对实验性自身免疫性脑脊髓炎脊髓中趋化因子MCP-1表达的影响[J].中华神经医学杂志,2007,6(3):290-292. 被引量：5
  • 3Niwa M,Inao S,Takayasu M,et al.Time course of expre-ssion of three nitric oxide synthase isoforms after transient middle cerebral artery occlusion in rats[J].Neuro Med Chir,2001,41:63-72.
  • 4Iadecola C.Bright and dark sides of nitric oxide in ischemic brain injury[J].Trends Neurosci,1997,20:132-139.
  • 5Olivenza R,Moro M A,Lizasoain I,et al.Chronic stress induces the expression of inducible nitric oxide synthase in rat brain cortex[J].Neurochemistry,2000,74:785-791.
  • 6Youssef S, Stuve O, Patarroyo JC, et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease [J]. Nature, 2002, 420(6911): 78-84.
  • 7Nath N, Girl S, Prasad R, et al. Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy[J]. J Immunol, 2004, 172 (2) 1273-1286.
  • 8Waiczies S, Bendix I, Prozorovski T, et al. Geranylgeranylation but not GTP loading determines rho migratory fuction in T cells [J]. J Immunol, 2007, 179 (9): 6024-6032.
  • 9Schulz JG, Bosel J, Stoeckel M, et al. HMG-CoA reductase inhibition causes neurite 1 oss by interfering with geranylgeranylpyrophosphate synthesis [J]. J Neurochem, 2004, 89(1): 24-32.
  • 10Jeong EM, Moon CH, Kim CS, et al. Cadmium stimulates the expression of ICAM-1 via NF-kappa B activation in cerebrovascular endothelial cells [J]. Biochem Biophys Res Commun, 2004, 320(3): 887-892.

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山东医药
2009年 第20期

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