摘要
目的 探讨齐拉西酮、利培酮对偏执型分裂症患者的视觉传入通路认知抑制功能的影响情况.方法 将124名患者分成齐拉西酮组（n=61）、利培酮组（n=63）.采用开放性的研究方法,使用规定剂量范围内的齐拉西酮、利培酮单一治疗8周,应用色词测试（CWT）及持续操作测试（CPT）评估认知抑制功能,应用阳性和阴性症状量表（PANSS）评估患者的临床症状变化,并记录不良反应.结果 齐拉西酮组治疗后CWT错误数（3.12±5.23）个、每正确反应平均耗时[（1.92±1.38）s]和CPT2位数、3位数认错数[（2.31 ±3.76）个、（3.15±2.80）个]均较治疗前的[（4.60 ±6.80）个、（2.74±1.52）s、（3.85±3.62）个、（4.42 ±3.53）个]有所改善（P＜0.05）;利培酮组治疗后CPT2位数认错数[（3.39±3.59）个]较治疗前[（4.23±3.88）个]有所改善（P＜0.05）.治疗后齐拉西酮组在CWT的每正确反应平均耗时上及CPT2位数、3位数认错数上均优于利培酮组（P＜0.05）.结论 齐拉西酮、利培酮均能在一定程度上改善偏执型分裂症视觉传入通路的认知抑制功能,齐拉西酮的短期效果优于利培酮.
Objective To explore the effects of ziprasidone and risperidone on cognitive inhibition function through visual pathway of patients with paranoid schizophrenia.Methods In the open-label,flexible-dosage trial,124 patients with paranoid schizophrenia were randomly divided into ziprasidone group （120-160 mg/d）and risperidone group（4-8 mg/d） for treatment of 8 weeks.They were assessed with computerized Color Word Test （CWT） and Continuous Performance Test（CPT） through visual pathway for cognitive inhibition function,Positive and Negative Syndrome Scale for efficacy on baseline and 8th weekend.Results After treatment with ziprasidone,the error number （3.12 ± 5.23 ）,the time per correct answer（ （ 1.92 ± 1.38 ） s） of CWT,as well as the doubledigit mistaken number （2.31 ± 3.76）and the three-figure mistaken number（ 3.15 ±2.80） of CPT reduced more than those before medication （ （4.60 ± 6.80）,（ 2.74 ± 1.52 ） s,（3.85 ± 3.62 ）,（4.42 ± 3.53 ） ） （P 〈 0.05 ）.In risperidone.group,the double-digit mistake number of CPT（3.39 ± 3.59） after pharmacotherapy reduced more than that before pharmacotherapy（4.23 ± 3.88） （P〈 0.05）.After treatment the time per correct answer of CWT and the mistaken numbers of CPT in ziprasidone group were less than those in risperidone group（P〈 0.05 ）,meanwhile,the scores of PANSS in two groups were significantly lower than those before treatment （P 〈 0.01 ）.Conclusion It is effective for ziprasidone and risperidone to improve the function of cognitive inhibition on patients with paranoid schizophrenia,but there is more dramatic for ziprasidone in short-term treatment.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2012年第8期716-718,共3页
Chinese Journal of Behavioral Medicine and Brain Science
基金
山东省医药卫生科技发展计划面上项目（2009年第HW057号）
山东省精神卫生中心院级科研项目
关键词
齐拉西酮
利培酮
偏执型分裂症
认知抑制
Ziprasidone
Risperidone
Paranoid schizophrenia
Cognitive inhibition
