摘要
目的探讨心脏型脂肪酸结合蛋白（H-FABP）在急性心肌梗死（AMI）早期诊断中的应用价值。方法检测60例疑似AMI患者H—FABP、心肌肌钙蛋白（cTn）T、肌酸激酶同工酶．MB（CK-MB）水平，按发病时间分为〈6h、6～12h两个时段，计算各项指标诊断AMI的灵敏度，同时测定15例非AMI疑似患者及45例健康体检者的H-FABP、cTnT、CK-MB水平，计算各项指标诊断AMI的特异度。结果H-FABP在发病〈6h诊断AMI的灵敏度为94％，明显优于cTnT的50％、CK-MB的56％，差异均有统计学意义（P〈0．05）；在发病6～12h，H—FABP诊断AMI的灵敏度为100％、cTnT为92％、CK-MB为92％，差异无统计学意义。三项指标诊断AMI的特异度比较差异无统计学意义。结论H—FABP对AMI早期诊断有较高的灵敏度和特异度，适用于胸痛患者的筛查及早期诊断AMI。
Objective To explore the value of heart-type fatty acid-binding protein （H-FABP） in the early diagnosis of acute myocardial infarction （AMI）. Methods Sixty confirmed AMI patients were observed, the data of H-FABP, cardiac troponin T （cTnT）, creatine kinase MB （CK-MB） were detected in 〈 6 h and 6-12 h after the symptoms appeared, and the sensitivity of the three markers was calculated. The specificity was compared with 15 uncertain AMI patients and 45 healthy subjects. Results The early diagnosis sensitivity of H-FABP in 〈 6 h was 94% in AMI, which was higher than that of cTnT （50%） and CK-MB （56%） （P 〈 0.05 ）. The diagnosis sensitivity of H-FABP, cTnT, CK-MB in 6-12 h was 100%, 92%, 92% respectively （P 〉 0.05 ）. There was no significant difference in the specificity among the three markers （P 〉 0.05）. Conclusions H-FABP has more sensitivity and specificity in the early diagnosis of AMI. It is apphcable in the screening of patients who suffered chest pain and the diagnosis of early AMI.
出处
《中国医师进修杂志（内科版）》
2009年第5期13-15,共3页
Chinese Journal of Postgraduates of Medicine
基金
贵州省优秀科技教育人才省长专项基金（黔省专合字2008-88）
关键词
心肌梗死
心脏标志物
心脏型脂肪酸结合蛋白
Myocardial infarction
Cardiac markers
Heart-type fatty acid-binding protein
