摘要
目的探讨血清心肌型脂肪酸结合蛋白(H-FABP)在早期急性冠脉综合征(ACS)中的临床诊断价值。方法应用全自动化学发光、生化分析仪检测46例ACS患者入院3～6 h及6～12 h两个时间段的血清中的H-FABP、肌钙蛋白I(cTnI)、肌红蛋白(MYO)、肌酸激酶同工酶(CK-MB)。结果 H-FABP表现出了很好的检测早期(3～6 h)ACS的效果,比MYO、cTnI和CK-MB效果均要好(P<0.05),单独检测的灵敏度达到了82.61%,而MYO、肌钙蛋白和CK-MB的诊断效果在6～12 h段有明显提高。结论 H-FABP具有很好的早期诊断ACS价值,可以将H-FABP作为更早期诊断ACS的心肌损伤标志物应用于临床检测中。
Objective To evaluate the clinical diagnosis value of H-FABP for early acute coronary syndrome（ACS）.Methods Serum H-FABP,cTnI,myoglobin and CK-MB were detected by automatic chemiluminescence and biochemistry analyzer 3～6 and 6～12 hours after the onset of chest pain in 38 patients suspected for ACS.Results H-FABP demonstrated a very good efficacy for the early detection（3～6 hours after the onset of chest pain） of ACS,while the levels of myoglobin,cTnI and CK-MB were sharply increased 6～12 hours after the onset of chest pain.In addition,H-FABP detection sensitivity reached 94.73%.Conclusion H-FABP is of good clinical diagnosis value.It may be use as the marker of early myocardial damage for the early detection of ACS.
出处
《临床和实验医学杂志》
2012年第19期1535-1536,共2页
Journal of Clinical and Experimental Medicine
