摘要
目的:探讨老年女性2型糖尿病患者高血压与骨质疏松(osteoporosis,OP)、骨密度(bone mineral density,BMD)的关系。方法:将179例老年女性T2DM患者分为2组,高血压组124例,非高血压组55例。测量腰椎和髋部的BMD。χ2检验比较2组总OP、腰椎OP、髋部OP的患病率,协方差分析各部位BMD的差别,并用二元logistic逐步回归方法分析OP与相关危险因素之间的相关性。结果:非高血压组总OP、腰椎OP、髋部OP的患病率均高于高血压组(P值分别为P总=0.037、P腰=0.042、P髋=0.051)。2组BMD比较,高血压组各部位的BMD均高于非高血压组,其中L3、L4BMD差异有统计学意义(P值分别为P3=0.040,P4=0.021)。但在校正体质量指数(body mass index,BMI)后P值均明显增大,2组BMD均无统计学差异,在校正C肽后P值也变大,但无校正BMI后P值变化明显。应用二元Logistic回归方法进行分析,年龄、BMI、骨钙素与OP有关,而高血压与OP无明显的相关。结论:OP与年龄、BMI、骨钙素有关,而高血压与OP之间没有必然的联系。
Objective： To investigate the relationship of hypertension with osteoporosis （OP）and bone mineral density （BMD） in elderly type 2 diabetic women. Methods： A total of 179 elderly type 2 diabetic women were categorized into hypertension group（n = 124）and non-hypertension group（n = 55）. Lumbar and hip BMD were measured by dual-energy X-ray absorptiometry. Prevalences of osteoporosis were compared between the two groups using Chi-square test, and BMD was compared using covariance analysis. The correlation between the osteoporosis and risk factors was analyzed using binary logistic regression method. Results： The prevalences of osteoporosis（total OP, lumber OP and hip OP） in non-hypertension group were higher than that of the hypertension group（Pt= 0. 037, P1=0. 042 and Ph =0. 051, respectively）. Lumbar and hip BMD in the hypertension group was higher than that in the non-hypertension group, and there were significant differences in L3 and L4 BMDs between the two groups （P3 = 0. 040,P4= 0. 021） ; however, the difference disappeared after adjustment for body mass index （BMD）. After adjustment for C peptide, the P value also increased, but not as obvious as after adjustment for BMI. Binary logistic regression analysis showed that OP was associated with age, BMI and osteocalcin, but not with hypertension. Conclusion： OP is associated with the age, BMI, and osteoealcin, but not with hypertension in elderly type 2 diabetic women.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2009年第4期424-427,共4页
Academic Journal of Second Military Medical University
关键词
2型糖尿病
骨质疏松
体质量指数
高血压
老年人
女性
type 2 diabetes mellitus
osteoporosis
body mass index
hypertension
aged
female
