摘要
目的探讨2型糖尿病（type 2 diabetes，T2DM）患者骨质疏松（osteoporosis，OP）和血脂的相关性。方法将296例2型糖尿患者按性别分为两组，男106例，女190例。再按其是否合并OP，将上述2组患者再分成2组。比较各组骨密度（BMD）与血脂的相关性。并用二元logist逐步回归方法分析血脂和其他相关因素与OP之间的相关性。结果合并OP的女性T2DM患者甘油三酯（TG）与LI、k、L4的BMD值成正相关（r1=0．302、P1=0．004、r3=0．221、P3=0．039、r4=0．208、P4=0．045），高密度脂蛋白胆固醇（HDL-c）与L1、Neck骨密度成负相关（r1=-0．237、P1：0．026、rN=-0．265、P2=0．013）。未合并OP的女性T2DM患者及男性患者未得到相同的结论，但上述结果在校正年龄和BMI因素后相关关系消失。应用二元logistic回归方法进行分析，只有年龄、性别、体重指数（body mass index，BMI）与OP有关。结论未观察到OP和血脂之间有必然的联系。
Objective To investigate the association of osteoporosis （OP） and plasma hpid in type 2 diabetic patients. Methods A total of 296 type 2 diabetic patients were categorized into men （ 106）, women （190） groups. Each group was categorized into osteoporosis, and non-osteoporosis group. Bone mineral density （BMD） and lipid were compared among each group. The correlation between the osteoporosis and risk factors was analyzed using logistic regression method. Results Type 2 diabetic women with osteoporosis showed a positive relationship between L1, L3, L4 BMD and triglycerides （ r1 = 0. 302, P1 = 0. 004, r3 = 0. 221, P3 = 0. 039, 1,4 = 0. 208, P4 = 0. 045 ） and a negative relationship between L1, Neck BMD with HDL-C （r1 = -0. 237, P1 =0. 026. rN = -0. 265. p2 =0. 013）. After adjustment for age and BMI, the effect disappeared. When a logistic regression analysis was performed, only age, sex and BMD were found to be associated with the presence of osteoporosis. Conclusion There was no relationship between BMD and lipid obseved in type 2 diabetic patients.
出处
《中华骨质疏松和骨矿盐疾病杂志》
2009年第2期107-112,共6页
Chinese Journal Of Osteoporosis And Bone Mineral Research
关键词
2型糖尿病
骨密度
血脂
体重指数
type 2 diabetes
bone mineral density
lipid
body mass index
