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转化生长因子β_1对Ⅰ型胶原基因转录的调节 被引量：6

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摘要 在肝纤维化形成进程中,早期以Ⅲ型胶原增加为主,随着病理的发展,胶原生成主要由Ⅲ型向Ⅰ型转变,这一现象为肝纤维化病理过程中的一个明显特征。研究Ⅰ型胶原生成增加的机制,已是肝纤维化研究的重要一环。转化生长因子β<sub>1</sub>（transforming growth factor β<sub>1</sub>,TGFβ<sub>1</sub>）在肝纤维化发生过程中,对Ⅰ型胶原蛋白的积聚起着关键的作用。因此,了解TGFβ<sub>1</sub>对Ⅰ型胶原基因表达的调节,可以更深入地认识肝纤维化的病理生物学机制,有助于对肝纤维化的发生发展进行防治。
作者 王晓玲 刘平 刘成
机构地区 上海中医药大学肝病研究所
出处 《中西医结合肝病杂志》 CAS 1998年第S1期196-199,共4页 Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
关键词 转化生长因子β<sub>1</sub> 启动子 肝纤维化 Ⅰ型胶原 基因转录 顺式作用元件 转录调节因子 结合位点 肝星状细胞 结合活性
分类号 R575.2 [医药卫生—消化系统]
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参考文献14

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同被引文献24

  • 1张灵芝,赵元昌,韩德五,陈贤明,许瑞龄,尹镭,马学惠.丹参在抗肝细胞坏死中的钙拮抗作用[J].中国病理生理杂志,1993,9(2):191-195. 被引量：40
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引证文献6

二级引证文献28

中西医结合肝病杂志
1998年 第S1期

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