摘要
肝纤维化是多种病因所致慢性肝炎的共同病理变化,特征在于肝脏细胞外基质异常增生与过度沉积,其核心环节在于肝星状细胞的活化。近年来,丹参及其有效成分在抗肝纤维化研究中取得了许多进展。丹参抗肝纤维化作用机制主要有:抗自由基过氧化损伤、促进损伤肝细胞的修复、抑制炎性因子释放、改善肝脏微循环、抑制胶原生成、促进病理沉积胶原的降解、抑制HSC活化。
Hepatic fibrosis is a common pathological change of chronic hepatitis resulted from etiopathogenisis with the characteristic of paraplasm and excessive deposition of extracellular a variety meterical （ECM） ,the core of which is activation of hepatic sellate cell.In recent years,the research of salvia miltiorrbiza and its active components about depressing hepatic fibrosis has made a great progress.The main mechanism of depressing production of collagen, promoting degradation of liver,depressing production of collagen,promoting degradation of collagen deposited in pathologicl process and depressing the activation of HBC.
出处
《现代诊断与治疗》
CAS
2008年第1期30-33,共4页
Modern Diagnosis and Treatment
关键词
丹参
肝纤维化
作用机制
Salivia miltiorrhiza
Hepatic fibrosis
Mechanism
