摘要
目的研究脂微球携载前列腺素E1(Lipo-PGE1)对闭塞性动脉硬化症(ASO)患者血管内皮功能的影响。方法将65例ASO患者随机分为两组,Lipo-PGE1治疗组38例在常规治疗基础上加用Lipo-PGE(110μg/d),静脉滴注,共2个疗程,常规治疗组27例仅接受常规治疗。观察治疗前和治疗2个月后血清内皮素(ET)、一氧化氮(NO)、血管性假血友病因子(Von Willebrand factor,vWF)、6酮前列腺素F1α(6-K-PGF1α)水平的变化。结果①常规治疗组治疗后ET显著降低(P<0.01),NO显著升高(P<0.01),vWF有下降趋势,6-K-PGF1α有升高趋势,但均未达统计学意义;②Lipo-PGE1治疗组治疗后ET、vWF水平显著降低(P<0.01),NO、6-K-PGF1α水平显著升高(P<0.01);③治疗后Lipo-PGE1治疗组NO、6-K-PGF1α水平高于常规治疗组(P<0.01),ET、vWF水平低于常规治疗组(P<0.01)。结论Lipo-PGE1可能通过降低血清ET、vWF,提高NO、6-K-PGF1α水平等途径改善闭塞性动脉硬化症患者血管内皮功能,提高临床疗效。
Objective To evaluate the effect of liposomal prostaglandin E1 （ Lipo-PGE1 ） on vascular endothelial function in patients with arterilsclerotic obliterance （ASO）. Methods Sixty-five ASO patients were randomly divided into two group, the 38 patients in therapy group treated by conventional therapy plus Lipo-PGE1 and the 27 patients in control group treated by conventional therapy alone. The changes of endothelin （ET）, nitric oxide （NO）, Von Willebrand factor（vWF）, and 6-keto-prostaglandin F1 alpha （6-K-PGF1α） levels in blood from before treatment to two months after treatment were observed. Results In conventional therapy group ,the level of blood ET was obviously decreased （P 〈 0.01 ）, and the level of NO was increased （P 〈 0. 01 ）. The levels of blood vWF and 6-K-PGF1α were also changed, but there weren＇t statistical meaning.②In Lipo-PGE1 therapy group, the levels of vWF , ET were lowered（ P 〈 0.01 ）, and the levels of NO and 6-K-PGF1α were elevated （P 〈 0.01 ）. ③After treatment compared with the conventional therapy group, the level of NO and 6-K-PGF1α were obvious higher（P 〈0.01 ） ,and the level of vWF , ET were lower（P 〈0.01 ）. Conclusion Lipo-PGE1 may protect vascular endothelium,improve clinical therapeutic effect by decreasing the levels of blood ET , vWF, and increasing the levels of NO and 6-K-PGF1α.
出处
《咸宁学院学报（医学版）》
2009年第1期22-24,共3页
Journal of Xianning Univarsity(medical Sciences)
