摘要
实验ＳＤ大鼠随机分为正常组、ＣＣｌ４组、川芎嗪组和秋水仙碱组。实验结果显示：与ＣＣｌ４组比较，川芎嗪组血清ＡＬＴ、丙二醛（ＭＤＡ）、Ⅲ型前胶原（ＰＣⅢ）、透明质酸（ＨＡ）及肝组织ＭＤＡ明显减低，肝组织超氧化物歧化酶（ＳＯＤ）活性显著提高，胶原纤维增生程度显著减轻，结蛋白（Ｄｅｓｍｉｎ）阳性细胞显著减少。两治疗组之间，血清ＰＣⅢ、ＨＡ及肝组织Ｄｅｓｍｉｎ阳性细胞数和胶原纤维增生程度无显著差异。表明川芎嗪有明显保护肝细胞、抗脂质过氧化和肝纤维化作用。秋火仙碱抗肝纤维化效应与之相似，但无抗脂质过氧化和保护肝细胞作用。
The SD rats were randomly divided into normal group, CCl 4、TMP and colchicine groups. The experiment results showed that the activities of serum ALT, the contents of malondialdehyde (MDA),PCⅢ、HA in serum and MDA in hepatic tissue of TMP group were significantly lower. The activities of SOD in hepatic tissue of TMP group were significantly higher, the degrees of proliferation of collagen fibers, the numbers of desmin positive cells in hepatic tissue of TMP group were significantly lower than those in CCl 4 group, wherease there were no significant differences in the levels of serum PCⅢ and HA, the contents of HA, the numbers of desmin positive cells and the degrees of collagen fiber proliferation in hepatic tissue between TMP group and colchicine group. This experiment suggests that the anti hepatofibrotic efficacies of TMP and colchicine are similar but their effect mechanisms are different. Colchicine has no the protective effect, which TMP has, no hepatocytes against lipid peroxidation.
出处
《中国野生植物资源》
1998年第1期6-9,共4页
Chinese Wild Plant Resources
关键词
川芎嗪
肝纤维化
脂质过氧化
秋水仙碱
Tetramethylpyrazine
Colchicine
Experiment liver fibrosis
Lipid peroxidation
