摘要
观察６２例慢性肾衰患者ＲＢＣ－ＳＯＤ活性、ＲＢＣ－ＬＰＯ浓度和红细胞免疫功能，结果表明，肾衰患者ＲＢＣ－ＳＯＤ活性较对照组降低（Ｐ＜０．０１），ＲＢＣ－ＬＰＯ浓度较对照组明显升高（Ｐ＜０．０１）；红细胞Ｃ３ｂ受体花环率（ＲＢＣ－Ｃ３ｂＲＲ）、红细胞免疫粘附促进因子（ＲＦＥＲ）活性较对照组明显降低（Ｐ均＜０．０１），红细胞免疫复合物花环率（ＲＢＣ－ＩＣＲ）、红细胞免疫粘附抑制因子（ＲＦＩＲ）活性较对照组明显升高。ＲＢＣ－ＳＯＤ活性与ＲＢＣ－Ｃ３ｂＲＲ呈正相关，与ＲＢＣ－ＩＣＲ呈负相关，ＲＢＣ－ＬＰＯ浓度与ＲＢＣ－Ｃ３ｂＲＲ呈负相关（Ｐ＜０．０１），与ＲＢＣ－ＩＣＲ浓度呈正相关（Ｐ＜０．０５），提示肾衰患者红细胞内抗氧化能力降低，脂质过氧化反应增强，红细胞免疫粘附功能降低，红细胞免疫粘附调节功能紊乱；红细胞ＳＯＤ活性、红细胞ＬＰＯ浓度能直接影响ＲＢＣ－Ｃ３ｂＲＲ的活性，进而影响红细胞清除免疫复合物的能力，与红细胞免疫功能的强弱有直接关系。
Erythrocyte superoxide dismutase(RBCSOD),erythrocyte lipid peroxide(RBCLPO)and immunologic function of red cells were measured synchronously in 62 cases of chronic renal failure(CRF)and in a healthy control group of 50 cases.The results are as follows:RBCSOD decreased remarkably while RBCLPO increased remarkably compared with the normal control(P<0.01);RBC C3b receptor rosette(RBCC3bRR)and RBC immune adherence enhance factor(RFER)decreased obviously while red cell immune complex rosette(RBCICR)and RBC immune adherence inhibitor factor(RFIR)increased obviously compared with the control group(P<0.01).RBCSOD was positively correlated with RBCC3bRR (P<0.01)while RBCICR was negatively correlated(P<0.01);a correlation between RBCLPO with RBCC3bRR was signiticantly negative(P<0.01)and with RBCICR was significantly positive (P<0.01).The results indicate that patients with CRF have decreased activities of antioxidation and increased lipid peroxide;immune adherence function of red cells decreases,immune adherence regulatory function of red cells is in disorder;RBCSOD activity and RBCLPO concentration can affect the immunologic function of red cells.
出处
《山东医科大学学报》
1998年第1期56-58,共3页
Acta Academiae Medicinae Shandong
关键词
肾功能衰竭
SOD
过氧化脂质
红细胞免疫
Renal failure,chronic
Superoxide dismutase
Lipid peroxides
Immunity
Erythrocyte
